CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FRG1 
Protein Synonyms/Alias
 FSHD region gene 1 protein 
Gene Name
 FRG1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MAEYSYVKSTKLVLKubiquitination[1, 2, 3]
11YSYVKSTKLVLKGTKubiquitination[3]
115ALKSGYGKYLGINSDubiquitination[3]
146EPVFQNGKMALLASNubiquitination[3]
170GDIEAKSKTAGEEEMubiquitination[3]
179AGEEEMIKIRSCAERubiquitination[3]
199DDIPEEDKGNVKQCEacetylation[4]
211QCEINYVKKFQSFQDubiquitination[3]
212CEINYVKKFQSFQDHubiquitination[3]
220FQSFQDHKLKISKEDubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be involved in pre- mRNA splicing. 
Sequence Annotation
 MOTIF 22 32 Nuclear localization signal (Potential).
 MOTIF 235 251 Bipartite nuclear localization signal  
Keyword
 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Ribosome biogenesis; rRNA processing; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MAEYSYVKST KLVLKGTKTK SKKKKSKDKK RKREEDEETQ LDIVGIWWTV TNFGEISGTI 60
AIEMDKGTYI HALDNGLFTL GAPHKEVDEG PSPPEQFTAV KLSDSRIALK SGYGKYLGIN 120
SDGLVVGRSD AIGPREQWEP VFQNGKMALL ASNSCFIRCN EAGDIEAKSK TAGEEEMIKI 180
RSCAERETKK KDDIPEEDKG NVKQCEINYV KKFQSFQDHK LKISKEDSKI LKKARKDGFL 240
HETLLDRRAK LKADRYCK 258 
Gene Ontology
 GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010414; FRG1. 
Pfam
 PF06229; FRG1 
SMART
  
PROSITE
  
PRINTS