UniProt Accession

 B4DW73_HUMAN; B4DW73 

Genbank Protein ID

 AL136295; AK301400; AK316206 

Genbank Nucleotide ID

 BAG62935.1; BAH14577.1 

Protein Name

 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial 

Protein Synonyms/Alias

 cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32); cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32) 

Gene Name

 PCK2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	GGNSLLGKKCFALRI	ubiquitination	[1, 2]
128	GNSLLGKKCFALRIA	ubiquitination	[2]
160	GITSPAGKKRYVAAA	ubiquitination	[3]
444	TPIGLVPKEGALDLS	ubiquitination	[3]
466	TQLFSLPKDFWEQEV	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Pyruvate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 506 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:InterPro.
 GO:0006094; P:gluconeogenesis; IEA:InterPro. 

Interpro

 IPR018091; PEP_carboxykin_GTP_CS.
 IPR013035; PEP_carboxykinase_C.
 IPR008209; PEP_carboxykinase_GTP.
 IPR008210; PEP_carboxykinase_N. 

Pfam

 PF00821; PEPCK 

SMART

  

PROSITE

 PS00505; PEPCK_GTP 

PRINTS