UniProt Accession

 GSH0_RAT; P48508 

Genbank Protein ID

 S65555; L22191; BC078867 

Genbank Nucleotide ID

 AAB28225.1; AAA41543.1; AAH78867.1 

Protein Name

 Glutamate--cysteine ligase regulatory subunit 

Protein Synonyms/Alias

 GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit 

Gene Name

 Gclm 

Gene Synonyms/Alias

 Glclr 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
90	PDEREEMKVSAKLFI	acetylation	[1]
255	LRYSVIVKSRGIIKS	acetylation	[1]
270	KGYILQAKRKGS***	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 MOD_RES 263 263 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glutathione biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0017109; C:glutamate-cysteine ligase complex; IDA:RGD.
 GO:0004357; F:glutamate-cysteine ligase activity; IDA:RGD.
 GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; ISS:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; IDA:RGD.
 GO:0006534; P:cysteine metabolic process; IEA:Compara.
 GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.
 GO:0006750; P:glutathione biosynthetic process; ISS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
 GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; IDA:RGD.
 GO:0050880; P:regulation of blood vessel size; ISS:UniProtKB.
 GO:0051900; P:regulation of mitochondrial depolarization; IEA:Compara.
 GO:0042493; P:response to drug; ISS:UniProtKB.
 GO:0051409; P:response to nitrosative stress; IMP:RGD.
 GO:0006979; P:response to oxidative stress; ISS:UniProtKB. 

Interpro

 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS