UniProt Accession

 ARGI1_RAT; P07824; Q5BK93 

Genbank Protein ID

 J02720; M17931; M17924; M17925; M17926; M17927; M17928; M17929; M17930; BC091158 

Genbank Nucleotide ID

 AAA40761.1; AAA40760.1; AAA40760.1; AAA40760.1; AAA40760.1; AAA40760.1; AAA40760.1; AAA40760.1; AAA40760.1; AAH91158.1 

Protein Name

 Arginase-1 

Protein Synonyms/Alias

 Liver-type arginase; Type I arginase 

Gene Name

 Arg1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MSSKPKPIEIIGA	acetylation	[1]
26	QPRGGVEKGPAALRK	acetylation	[1]
39	RKAGLVEKLKETEYN	acetylation	[1]
41	AGLVEKLKETEYNVR	acetylation	[1]
68	DSPFQIVKNPRSVGK	acetylation	[1]
75	KNPRSVGKANEQLAA	acetylation	[1]
191	PGEHYIIKTLGIKYF	acetylation	[1]
196	IIKTLGIKYFSMTEV	acetylation	[1]
205	FSMTEVDKLGIGKVM	acetylation	[1]
284	EVNPTLGKTPEEVTR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 REGION 126 130 Substrate binding.
 REGION 137 139 Substrate binding.
 METAL 101 101 Manganese 1.
 METAL 124 124 Manganese 1.
 METAL 124 124 Manganese 2.
 METAL 126 126 Manganese 2.
 METAL 128 128 Manganese 1.
 METAL 232 232 Manganese 1.
 METAL 232 232 Manganese 2.
 METAL 234 234 Manganese 2.
 BINDING 183 183 Substrate.
 MOD_RES 3 3 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).  

Keyword

 3D-structure; Arginine metabolism; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Phosphoprotein; Reference proteome; Urea cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0004053; F:arginase activity; IDA:RGD.
 GO:0030145; F:manganese ion binding; IDA:RGD.
 GO:0006525; P:arginine metabolic process; IDA:RGD.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
 GO:0071377; P:cellular response to glucagon stimulus; IEP:RGD.
 GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
 GO:0071353; P:cellular response to interleukin-4; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
 GO:0032964; P:collagen biosynthetic process; IMP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0030324; P:lung development; IEP:RGD.
 GO:0060056; P:mammary gland involution; IEP:RGD.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:RGD.
 GO:0070207; P:protein homotrimerization; IDA:RGD.
 GO:0010963; P:regulation of L-arginine import; IDA:RGD.
 GO:0014075; P:response to amine stimulus; IEP:RGD.
 GO:0043200; P:response to amino acid stimulus; IEP:RGD.
 GO:0048678; P:response to axon injury; IEP:RGD.
 GO:0046686; P:response to cadmium ion; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009635; P:response to herbicide; IEP:RGD.
 GO:0010042; P:response to manganese ion; IEP:RGD.
 GO:0051597; P:response to methylmercury; IEP:RGD.
 GO:0010269; P:response to selenium ion; IEP:RGD.
 GO:0033189; P:response to vitamin A; IEP:RGD.
 GO:0033197; P:response to vitamin E; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0000050; P:urea cycle; IDA:RGD. 

Interpro

 IPR014033; Arginase.
 IPR006035; Ureohydrolase.
 IPR023696; Ureohydrolase_domain.
 IPR020855; Ureohydrolase_Mn_BS. 

Pfam

 PF00491; Arginase 

SMART

  

PROSITE

 PS01053; ARGINASE_1
 PS51409; ARGINASE_2 

PRINTS

 PR00116; ARGINASE.