UniProt Accession

 MT1H_HUMAN; P80294; B2RUY6 

Genbank Protein ID

 X64834; X64177; BT007171; CH471092; BC008408; BC059780; BC146930; BC146934; S68948 

Genbank Nucleotide ID

 CAA46046.1; CAA45516.1; AAP35835.1; EAW82884.1; AAH08408.1; AAH59780.1; AAI46931.1; AAI46935.1; AAB30081.1 

Protein Name

 Metallothionein-1H 

Protein Synonyms/Alias

 MT-1H; Metallothionein-0; MT-0; Metallothionein-IH; MT-IH 

Gene Name

 MT1H 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	ICKGASEKCSCCA**	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. 

Sequence Annotation

 REGION 1 29 Beta.
 REGION 30 61 Alpha.
 METAL 5 5 Divalent metal cation; cluster B.
 METAL 7 7 Divalent metal cation; cluster B.
 METAL 13 13 Divalent metal cation; cluster B.
 METAL 15 15 Divalent metal cation; cluster B.
 METAL 19 19 Divalent metal cation; cluster B.
 METAL 21 21 Divalent metal cation; cluster B.
 METAL 24 24 Divalent metal cation; cluster B.
 METAL 26 26 Divalent metal cation; cluster B.
 METAL 29 29 Divalent metal cation; cluster B.
 METAL 33 33 Divalent metal cation; cluster A.
 METAL 34 34 Divalent metal cation; cluster A.
 METAL 36 36 Divalent metal cation; cluster A.
 METAL 37 37 Divalent metal cation; cluster A.
 METAL 41 41 Divalent metal cation; cluster A.
 METAL 44 44 Divalent metal cation; cluster A.
 METAL 48 48 Divalent metal cation; cluster A.
 METAL 50 50 Divalent metal cation; cluster A.
 METAL 57 57 Divalent metal cation; cluster A.
 METAL 59 59 Divalent metal cation; cluster A.
 METAL 60 60 Divalent metal cation; cluster A.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Cadmium; Complete proteome; Copper; Direct protein sequencing; Metal-binding; Metal-thiolate cluster; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 61 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0071276; P:cellular response to cadmium ion; IEP:UniProtKB.
 GO:0071294; P:cellular response to zinc ion; IEP:UniProtKB.
 GO:0045926; P:negative regulation of growth; ISS:UniProtKB. 

Interpro

 IPR017854; Metalthion_dom.
 IPR023587; Metalthion_dom_vert.
 IPR003019; Metalthion_sfam_euk.
 IPR000006; Metalthion_vert.
 IPR018064; Metalthion_vert_metal_BS. 

Pfam

 PF00131; Metallothio 

SMART

  

PROSITE

 PS00203; METALLOTHIONEIN_VRT 

PRINTS

 PR00860; MTVERTEBRATE.