CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039998
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Unconventional myosin-Ic 
Protein Synonyms/Alias
  
Gene Name
 MYO1C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
122SGESGAGKTEATKRLubiquitination[1]
127AGKTEATKRLLQFYAubiquitination[1]
164LEAFGNAKTLRNDNSubiquitination[2, 3]
337THRKIIAKGEELLSPubiquitination[3]
380INRSLASKDVESPSWubiquitination[2, 3, 4]
554KETMCSSKNPIMSQCubiquitination[1]
594LVEILQSKEPAYVRCubiquitination[4]
697KIFIRFPKTLFATEDubiquitination[2]
716RRQSLATKIQAAWRGubiquitination[2]
844RSISPEWKQQLQQKAubiquitination[2, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1039 AA 
Protein Sequence
MALGSDGVRV TMESALTARD RVGVQDFVLL ENFTSEAAFI ENLRRRFREN LIYTYIGPVL 60
VSVNPYRDLQ IYSRQHMERY RGVSFYEVPP HLFAVADTVY RALRTERRDQ AVMISGESGA 120
GKTEATKRLL QFYAETCPAP ERGGAVRDRL LQSNPVLEAF GNAKTLRNDN SSRFGKYMDV 180
QFDFKGAPVG GHILSYLLEK SRVVHQNHGE RNFHIFYQLL EGGEEETLRR LGLERNPQSY 240
LYLVKGQCAK VSSINDKSDW KVVRKALTVI DFTEDEVEDL LSIVASVLHL GNIHFAANEE 300
SNAQVTTENQ LKYLTRLLSV EGSTLREALT HRKIIAKGEE LLSPLNLEQA AYARDALAKA 360
VYSRTFTWLV GKINRSLASK DVESPSWRST TVLGLLDIYG FEVFQHNSFE QFCINYCNEK 420
LQQLFIELTL KSEQEEYEAE GIAWEPVQYF NNKIICDLVE EKFKGIISIL DEECLRPGEA 480
TDLTFLEKLE DTVKHHPHFL THKLADQRTR KSLGRGEFRL LHYAGEVTYS VTGFLDKNND 540
LLFRNLKETM CSSKNPIMSQ CFDRSELSDK KRPETVATQF KMSLLQLVEI LQSKEPAYVR 600
CIKPNDAKQP GRFDEVLIRH QVKYLGLLEN LRVRRAGFAY RRKYEAFLQR YKSLCPETWP 660
TWAGRPQDGV AVLVRHLGYK PEEYKMGRTK IFIRFPKTLF ATEDALEVRR QSLATKIQAA 720
WRGFHWRQKF LRVKRSAICI QSWWRGTLGR RKAAKRKWAA QTIRRLIRGF VLRHAPRCPE 780
NAFFLDHVRT SFLLNLRRQL PQNVLDTSWP TPPPALREAS ELLRELCIKN MVWKYCRSIS 840
PEWKQQLQQK AVASEIFKGK KDNYPQSVPR LFISTRLGTD EISPRVLQAL GSEPIQYAVP 900
VVKYDRKGYK PRSRQLLLTP NAVVIVEDAK VKQRIDYANL TGISVSSLSD SLFVLHVQRA 960
DNKQKGDVVL QSDHVIETLT KTALSANRVN SININQGSIT FAGGPGRDGT IDFTPGSELL 1020
ITKAKNGHLA VVAPRLNSR 1039 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR010926; Myosin_tail_2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00612; IQ
 PF00063; Myosin_head
 PF06017; Myosin_TH1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.