| Tag | Content |
|---|
| CPLM ID | CPLM-011456 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuole morphology and inheritance protein 14 |
Protein Synonyms/Alias | Swollen vacuole phenotype 2 protein |
Gene Name | VAC14 |
Gene Synonyms/Alias | SVP2; YLR386W; L3502.1 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 302 | RLKMLEDKYNNSSTP | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity. |
Sequence Annotation | REPEAT 82 119 HEAT 1.
REPEAT 243 280 HEAT 2.
REPEAT 388 425 HEAT 3.
REPEAT 429 466 HEAT 4.
REPEAT 517 554 HEAT 5.
MOD_RES 767 767 Phosphoserine.
MOD_RES 805 805 Phosphoserine.
MOD_RES 867 867 Phosphoserine. |
Keyword | Complete proteome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Vacuole. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 880 AA |
Protein Sequence | MEKSIAKGLS DKLYEKRKAA ALELEKLVKQ CVLEGDYDRI DKIIDELCRD YAYALHQPMA 60
RNAGLMGLAA TAIALGINDV GRYLRNILPP VLACFGDQND QVRFYACESL YNIAKIAKGE 120
ILVYFNEIFD VLCKISADTE NSVRGAAELL DRLIKDIVAE RASNYISIVN NGSHGLLPAI 180
KTDPISGDVY QEEYEQDNQL AFSLPKFIPL LTERIYAINP DTRVFLVDWL KVLLNTPGLE 240
LISYLPSFLG GLFTFLGDSH KDVRTVTHTL MDSLLHEVDR ISKLQTEIKM KRLERLKMLE 300
DKYNNSSTPT KKADGALIAE KKKTLMTALG GLSKPLSMET DDTKLSNTNE TDDERHLTSQ 360
EQLLDSEATS QEPLRDGEEY IPGQDINLNF PEVITVLVNN LASSEAEIQL IALHWIQVIL 420
SISPNVFIPF LSKILSVLLK LLSDSDPHIT EIAQLVNGQL LSLCSSYVGK ETDGKIAYGP 480
IVNSLTLQFF DSRIDAKIAC LDWLILIYHK APNQILKHND SMFLTLLKSL SNRDSVLIEK 540
ALSLLQSLCS DSNDNYLRQF LQDLLTLFKR DTKLVKTRAN FIMRQISSRL SPERVYKVIS 600
SILDNYNDTT FVKMMIQILS TNLITSPEMS SLRNKLRTCE DGMFFNSLFK SWCPNPVSVI 660
SLCFVAENYE LAYTVLQTYA NYELKLNDLV QLDILIQLFE SPVFTRMRLQ LLEQQKHPFL 720
HKCLFGILMI IPQSKAFETL NRRLNSLNIW TSQSYVMNNY IRQRENSNFC DSNSDISQRS 780
VSQSKLHFQE LINHFKAVSE EDEYSSDMIR LDHGANNKSL LLGSFLDGID EDKQEIVTPI 840
SPMNEAINEE MESPNDNSSV ILKDSGSLPF NRNVSDKLKK 880 |
Gene Ontology | GO:0000306; C:extrinsic to vacuolar membrane; IDA:SGD. GO:0000329; C:fungal-type vacuole membrane; IDA:SGD. GO:0070772; C:PAS complex; IDA:SGD. GO:0019209; F:kinase activator activity; IEA:InterPro. GO:0030674; F:protein binding, bridging; IMP:SGD. GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:SGD. GO:0033674; P:positive regulation of kinase activity; IMP:SGD. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |