CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006553
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromosomal replication initiator protein DnaA 
Protein Synonyms/Alias
  
Gene Name
 dnaA 
Gene Synonyms/Alias
 STM3838 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
54VLDWVRDKYLNNINGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. DnaA can inhibit its own gene expression as well as that of other genes (By similarity). 
Sequence Annotation
 NP_BIND 171 178 ATP (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN 60
GLLNTFCGAD APQLRFEVGT KPVTQTLKTP VHNVVAPAQT TTAQPQRVAP AARSGWDNVP 120
APAEPTYRSN VNVKHTFDNF VEGKSNQLAR AAARQVADNP GGAYNPLFLY GGTGLGKTHL 180
LHAVGNGIMA RKPNAKVVYM HSERFVQDMV KALQNNAIEE FKRYYRSVDA LLIDDIQFFA 240
NKERSQEEFF HTFNALLEGN QQIILTSDRY PKEINGVEDR LKSRFGWGLT VAIEPPELET 300
RVAILMKKAD ENDIRLPGEV AFFIAKRLRS NVRELEGALN RVIANANFTG RAITIDFVRE 360
ALRDLLALQE KLVTIDNIQK TVAEYYKIKI ADLLSKRRSR SVARPRQMAM ALAKELTNHS 420
LPEIGDAFGG RDHTTVLHAC RKIEQLREES HDIKEDFSNL IRTLSS 466 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003688; F:DNA replication origin binding; IEA:HAMAP.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0006270; P:DNA replication initiation; IEA:HAMAP.
 GO:0006275; P:regulation of DNA replication; IEA:HAMAP. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR001957; Chromosome_initiator_DnaA.
 IPR020591; Chromosome_initiator_DnaA-like.
 IPR018312; Chromosome_initiator_DnaA_CS.
 IPR013159; DnaA_C.
 IPR013317; DnaA_Hda.
 IPR024633; DnaA_N_dom.
 IPR027417; P-loop_NTPase.
 IPR010921; Trp_repressor/repl_initiator. 
Pfam
 PF00308; Bac_DnaA
 PF08299; Bac_DnaA_C
 PF11638; DnaA_N 
SMART
 SM00382; AAA
 SM00760; Bac_DnaA_C 
PROSITE
 PS01008; DNAA 
PRINTS
 PR00051; DNAA.