CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014072
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent multivitamin transporter 
Protein Synonyms/Alias
 Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6 
Gene Name
 Slc5a6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
577LLPLSCQKRLCWRSHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transports pantothenate, biotin and lipoate in the presence of sodium. 
Sequence Annotation
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 CARBOHYD 497 497 N-linked (GlcNAc...) (Potential).  
Keyword
 Biotin; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 634 AA 
Protein Sequence
MSVASTAAPF HTTSGSSGAI STFSVVDYVV FGLLLVLSLV IGLYHACRGW GHHTVGELLM 60
ADRKMGCLPV ALSLLATFQS AVAILGAPAE IFRFGTQYWF LGCSYFLGLL IPAHIFIPVF 120
YRLHLTSAYE YLELRFNKAV RICGTVTFIF QMVIYMGVAL YAPSLALNAV TGFDLWLSVL 180
ALGIVCNIYT ALGGLKAVIW TDVFQTLVMF LGQLVVIIVG AARVGGLGHV WNVTSQHGLI 240
SGINLDPDPF VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSERAAV LSCYAVFPCQ 300
QVALCMSCLI GLVMFAYYNM YSMSPELKQA APDQLVLYFV MDLLKDMPGL PGLFVACLFS 360
GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRG LAFAYGLVCL GMAYISSHLG 420
SVLQAALSIF GMVGGPLLGL FCLGLFFPCA NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS 480
AVAPPPLNGS SSFLPANVTV AAVTTVMPST LSKPTGLQHF YSLSYLWYSA HNSTTVIVVG 540
LIVSLLTGGM RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHSQDIPV IPNLFPEKMR 600
NGVLQDSTDK ERMAEDGLVH QPCSPTYVVQ ETSL 634 
Gene Ontology
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0012506; C:vesicle membrane; IEA:Compara.
 GO:0008523; F:sodium-dependent multivitamin transmembrane transporter activity; IEA:Compara.
 GO:0015878; P:biotin transport; IEA:Compara.
 GO:0015887; P:pantothenate transmembrane transport; IEA:Compara. 
Interpro
 IPR001734; Na/solute_symporter.
 IPR018212; Na/solute_symporter_CS.
 IPR019900; Na/solute_symporter_subgr. 
Pfam
 PF00474; SSF 
SMART
  
PROSITE
 PS00456; NA_SOLUT_SYMP_1
 PS00457; NA_SOLUT_SYMP_2
 PS50283; NA_SOLUT_SYMP_3 
PRINTS