CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014121
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM46C 
Protein Synonyms/Alias
  
Gene Name
 FAM46C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49PTLEITLKDIVQTVRubiquitination[1]
65RLEEAGIKVHDVRLNubiquitination[1, 2, 3]
126FLPEGVNKLKISPVTubiquitination[1]
128PEGVNKLKISPVTLKubiquitination[1, 2, 3]
135KISPVTLKEAYVQKLubiquitination[2]
141LKEAYVQKLVKVCTDubiquitination[2]
144AYVQKLVKVCTDTDRubiquitination[2]
163SLSNKNGKNVELKFVubiquitination[2]
168NGKNVELKFVDSIRRubiquitination[1, 4]
234QNRLIATKNPEEIRGubiquitination[1, 2, 3, 4]
246IRGGGLLKYSNLLVRubiquitination[1, 2, 4]
264PTDQEEIKTLERYMCubiquitination[1, 2, 4]
287DILEQQRKLETYLQNubiquitination[2]
303FAEEERSKYDYLMILubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon. 
Sequence Annotation
  
Keyword
 Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 391 AA 
Protein Sequence
MAEESSCTRD CMSFSVLNWD QVSRLHEVLT EVVPIHGRGN FPTLEITLKD IVQTVRSRLE 60
EAGIKVHDVR LNGSAAGHVL VKDNGLGCKD LDLIFHVALP TEAEFQLVRD VVLCSLLNFL 120
PEGVNKLKIS PVTLKEAYVQ KLVKVCTDTD RWSLISLSNK NGKNVELKFV DSIRRQFEFS 180
VDSFQIILDS LLFFYDCSNN PISEHFHPTV IGESMYGDFE EAFDHLQNRL IATKNPEEIR 240
GGGLLKYSNL LVRDFRPTDQ EEIKTLERYM CSRFFIDFPD ILEQQRKLET YLQNHFAEEE 300
RSKYDYLMIL RRVVNESTVC LMGHERRQTL NLISLLALRV LAEQNIIPSA TNVTCYYQPA 360
PYVSDGNFSN YYVAHPPVTY SQPYPTWLPC N 391 
Gene Ontology
  
Interpro
 IPR012937; DUF1693. 
Pfam
 PF07984; DUF1693 
SMART
  
PROSITE
  
PRINTS