UniProt Accession

 CATZ_MOUSE; Q9WUU7 

Genbank Protein ID

 AJ242663; AF136277; AF136278; BC008619 

Genbank Nucleotide ID

 CAB44494.1; AAF13143.1; AAF13144.1; AAH08619.1 

Protein Name

 Cathepsin Z 

Protein Synonyms/Alias

  

Gene Name

 Ctsz 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
162	TCNNYQAKDQDCDKF	acetylation	[1]
168	AKDQDCDKFNQCGTC	acetylation	[2]
273	WGEPWGEKGWMRIVT	acetylation	[2]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity (By similarity). 

Sequence Annotation

 ACT_SITE 94 94 By similarity.
 ACT_SITE 243 243 By similarity.
 ACT_SITE 264 264 By similarity.
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 226 226 N-linked (GlcNAc...) (Potential).
 DISULFID 91 134 By similarity.
 DISULFID 128 166 By similarity.
 DISULFID 156 172 By similarity.
 DISULFID 175 181 By similarity.
 DISULFID 216 299 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEP:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C. 

Pfam

 PF00112; Peptidase_C1 

SMART

 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.