| Tag | Content |
|---|
| CPLM ID | CPLM-007136 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | N-acetylneuraminate epimerase |
Protein Synonyms/Alias | N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase |
Gene Name | nanM |
Gene Synonyms/Alias | yjhT; b4310; JW5777 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 109 | QVFNDVHKYNPKTNS | acetylation | [1] | | 315 | IHLWHNGKWDKSGEL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. |
Sequence Annotation | REPEAT 40 84 Kelch 1.
REPEAT 86 137 Kelch 2.
REPEAT 139 173 Kelch 3.
REPEAT 174 219 Kelch 4.
REPEAT 222 265 Kelch 5.
REPEAT 287 336 Kelch 6.
REPEAT 338 367 Kelch 7.
ACT_SITE 228 228 Proton acceptor (Potential). |
Keyword | 3D-structure; Carbohydrate metabolism; Complete proteome; Isomerase; Kelch repeat; Periplasm; Reference proteome; Repeat; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 368 AA |
Protein Sequence | MNKTITALAI MMASFAANAS VLPETPVPFK SGTGAIDNDT VYIGLGSAGT AWYKLDTQAK 60
DKKWTALAAF PGGPRDQATS AFIDGNLYVF GGIGKNSEGL TQVFNDVHKY NPKTNSWVKL 120
MSHAPMGMAG HVTFVHNGKA YVTGGVNQNI FNGYFEDLNE AGKDSTAIDK INAHYFDKKA 180
EDYFFNKFLL SFDPSTQQWS YAGESPWYGT AGAAVVNKGD KTWLINGEAK PGLRTDAVFE 240
LDFTGNNLKW NKLAPVSSPD GVAGGFAGIS NDSLIFAGGA GFKGSRENYQ NGKNYAHEGL 300
KKSYSTDIHL WHNGKWDKSG ELSQGRAYGV SLPWNNSLLI IGGETAGGKA VTDSVLITVK 360
DNKVTVQN 368 |
Gene Ontology | GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc. GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoCyc. GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. |
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PRINTS | |