| Tag | Content |
|---|
| CPLM ID | CPLM-021004 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-coupled neutral amino acid transporter 3 |
Protein Synonyms/Alias | N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; mNAT; System N amino acid transporter 1 |
Gene Name | Slc38a3 |
Gene Synonyms/Alias | Sn1; Snat3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 17 | VELVPNGKHLEGLLP | ubiquitination | [1] | | 45 | TQHCGEGKGFLQKSP | ubiquitination | [1] | | 50 | EGKGFLQKSPSKEPH | ubiquitination | [1] | | 54 | FLQKSPSKEPHFTDF | ubiquitination | [1] | | 461 | FRIMPTDKEPARSTP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. |
Sequence Annotation | MOD_RES 51 51 Phosphoserine.
MOD_RES 53 53 Phosphoserine.
CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
CARBOHYD 251 251 N-linked (GlcNAc...) (Potential).
CARBOHYD 324 324 N-linked (GlcNAc...) (Potential). |
Keyword | Amino-acid transport; Antiport; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 505 AA |
Protein Sequence | MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK SPSKEPHFTD 60
FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF LLTAVALLSS YSIHLLLKSS 120
GIVGIRAYEQ LGYRAFGTPG KLAAALAITL QNIGAMSSYL YIIKSELPLV IQTFLNLEKP 180
ASVWYMDGNY LVILVSVTII LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP 240
LAHNLANATG NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC 300
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE SELLHTYSKV 360
DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN QEFSWLRHVL IATGLLTCIN 420
LLVIFAPNIL GIFGIIGATS APCLIFIFPA IFYFRIMPTD KEPARSTPKI LALCFAAVGF 480
LLMTMSLSFI IIDWVSGTSQ HGGNH 505 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:MGI. GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. GO:0015182; F:L-asparagine transmembrane transporter activity; IEA:Compara. GO:0015186; F:L-glutamine transmembrane transporter activity; IDA:MGI. GO:0005290; F:L-histidine transmembrane transporter activity; IDA:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |