CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015581
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TOM1-like protein 2 
Protein Synonyms/Alias
 Target of Myb-like protein 2 
Gene Name
 TOM1L2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
186DVVRGNTKVMSEMLTubiquitination[1]
350NSLAEQRKTVTYEDPubiquitination[1]
371ASALDNRKQSSEGIPubiquitination[1]
397VWLRTDLKGDDLEEGubiquitination[1]
419KFLEERAKAAEMVPDubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. 
Sequence Annotation
 DOMAIN 20 152 VHS.
 DOMAIN 219 307 GAT.
 MOTIF 329 334 Clathrin-binding.
 MOD_RES 160 160 Phosphoserine.
 MOD_RES 164 164 Phosphothreonine.
 MOD_RES 479 479 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MEFLLGNPFS TPVGQCLEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA IRALKKRLNG 60
NRNYREVMLA LTAWADAFRS SPDLTGVVHI YEELKRKGVE FPMADLDALS PIHTPQRSVP 120
EVDPAATMPR SQSQQRTSAG SYSSPPPAPY SAPQAPALSV TGPITANSEQ IARLRSELDV 180
VRGNTKVMSE MLTEMVPGQE DSSDLELLQE LNRTCRAMQQ RIVELISRVS NEEVTEELLH 240
VNDDLNNVFL RYERFERYRS GRSVQNASNG VLNEVTEDNL IDLGPGSPAV VSPMVGNTAP 300
PSSLSSQLAG LDLGTESVSG TLSSLQQCNP RDGFDMFAQT RGNSLAEQRK TVTYEDPQAV 360
GGLASALDNR KQSSEGIPVA QPSVMDDIEV WLRTDLKGDD LEEGVTSEEF DKFLEERAKA 420
AEMVPDLPSP PMEAPAPASN PSGRKKPERS EDALFAL 457 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR014645; TOM1.
 IPR027429; TOM1L2.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 
Pfam
 PF03127; GAT
 PF00790; VHS 
SMART
 SM00288; VHS 
PROSITE
 PS50909; GAT
 PS50179; VHS 
PRINTS