UniProt Accession

 DCA12_HUMAN; Q5T6F0; A8KA70; D3DRL6; Q5T6E9; Q5T6F1; Q6P3V0; Q7L4F8; Q96PZ5; Q9NXA9; Q9UFJ1 

Genbank Protein ID

 DQ518909; AB067479; AK000354; AK292935; AL354989; AL354989; AL354989; CH471071; CH471071; BC008893; BC063823; AL117646 

Genbank Nucleotide ID

 ABG24246.1; BAB67785.1; BAA91106.1; BAF85624.1; CAI15300.1; CAI15301.1; CAI15302.1; EAW58472.1; EAW58473.1; AAH08893.2; AAH63823.1; CAB56028.2 

Protein Name

 DDB1- and CUL4-associated factor 12 

Protein Synonyms/Alias

 Centrosome-related protein TCC52; Testis cancer centrosome-related protein; WD repeat-containing protein 40A 

Gene Name

 DCAF12 

Gene Synonyms/Alias

 KIAA1892; TCC52; WDR40A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	QQLPSLLKEREFHLG	ubiquitination	[1, 2]
219	VTDDVLTKSDARHNV	ubiquitination	[1, 3]
241	HITHKALKDIPKEDT	ubiquitination	[1]
254	DTNPDNCKVRALAFN	ubiquitination	[1, 2]
265	LAFNNKNKELGAVSL	ubiquitination	[1]
287	KAENTLSKLLSTKLP	ubiquitination	[1, 2]
292	LSKLLSTKLPYCREN	ubiquitination	[1]
384	LSACYGSKPRLAGEN	ubiquitination	[1]
393	RLAGENLKLTTGKGW	ubiquitination	[1, 2]
398	NLKLTTGKGWLNHDE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. 

Sequence Annotation

 REPEAT 138 178 WD 1.
 REPEAT 182 220 WD 2.
 REPEAT 250 289 WD 3.
 REPEAT 338 375 WD 4.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0080008; C:Cul4-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IC:UniProtKB. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS