UniProt Accession

 PSB4_MOUSE; P99026; Q3THC0; Q3THI3; Q3U0S0; Q3UVQ4; Q62008; Q8BK27; Q91VV7 

Genbank Protein ID

 U65636; AK077448; AK137044; AK156624; AK168265; AK168340; BC008241; M74556 

Genbank Nucleotide ID

 AAC53263.1; BAC36805.1; BAE23215.1; BAE33781.1; BAE40213.1; BAE40277.1; AAH08241.1; AAA39863.1 

Protein Name

 Proteasome subunit beta type-4 

Protein Synonyms/Alias

 Low molecular mass protein 3; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3 

Gene Name

 Psmb4 

Gene Synonyms/Alias

 Lmp3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
201	LLREVLEKQPVLSQT	acetylation	[1]
201	LLREVLEKQPVLSQT	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). 

Sequence Annotation

 ACT_SITE 46 46 Nucleophile (By similarity).
 MOD_RES 102 102 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; IDA:UniProtKB.
 GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IMP:UniProtKB.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. 

Interpro

 IPR016050; Proteasome_bsu_CS.
 IPR016295; Proteasome_endopept_cplx_B.
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 

Pfam

 PF00227; Proteasome 

SMART

  

PROSITE

 PS00854; PROTEASOME_B_1
 PS51476; PROTEASOME_B_2 

PRINTS