CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028618
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Four and a half LIM domains protein 1 
Protein Synonyms/Alias
  
Gene Name
 Fhl1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33KVGTMSEKFDCHYCRacetylation[1]
51QGKKYVQKDGRHCCLacetylation[1]
112ASETFVSKDGKILCNubiquitination[2]
147GDQNVEYKGTVWHKDacetylation[3]
173GTGSFFPKGEDFYCVacetylation[4]
186CVTCHETKFAKHCVKacetylation[1, 4]
307VYCPDCAKKL*****ubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MTFYVAFLAL KLIWMLSSPT GPSSYKVGTM SEKFDCHYCR DPLQGKKYVQ KDGRHCCLKC 60
FDKFCANTCV DCRKPISADA KEVHYKNRYW HDNCFRCAKC LHPLASETFV SKDGKILCNK 120
CATREDSPRC KGCFKAIVAG DQNVEYKGTV WHKDCFTCSN CKQVIGTGSF FPKGEDFYCV 180
TCHETKFAKH CVKCNKAITS GGITYQDQPW HAECFVCVTC SKKLAGQRFT AVEDQYYCVD 240
CYKNFVAKKC AGCKNPITGF GKGSSVVAYE GQSWHDYCFH CKKCSVNLAN KRFVFHNEQV 300
YCPDCAKKL 309 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS