CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043833
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calpain-7 
Protein Synonyms/Alias
  
Gene Name
 CAPN7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31YERRFNKKLITGIIYubiquitination[1]
42GIIYPQNKDGEPEYNubiquitination[1, 2]
53PEYNPCGKYMVKLHLubiquitination[1]
57PCGKYMVKLHLNGVPubiquitination[1]
77KLNISNLKIQNTPVIubiquitination[2]
94DQLPVDHKGELLCSYubiquitination[2]
157SDSQTFSKDNSFRMLubiquitination[1, 2, 3, 4, 5]
215GLRFIQLKNPWSHLRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
XFSIKQTIVS DCSFVASLAI SAAYERRFNK KLITGIIYPQ NKDGEPEYNP CGKYMVKLHL 60
NGVPRKNTYK LNISNLKIQN TPVIIDDQLP VDHKGELLCS YSNNKSELWV SLIEKAYMKV 120
MGGYDFPGSN SNIDLHALTG WIPERIAMHS DSQTFSKDNS FRMLYQRFHK GDVLITASTG 180
MMTEAEGEKW GLVPTHAYAV LDIREFKGLR FIQLKNPWSH LRWKGRYSEN DVKNWTPELQ 240
KYLNFDPR 248 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR001300; Peptidase_C2_calpain_cat. 
Pfam
 PF00648; Peptidase_C2 
SMART
 SM00230; CysPc 
PROSITE
 PS50203; CALPAIN_CAT 
PRINTS