UniProt Accession

 5NT3B_HUMAN; Q969T7; A8MWB9; C9JKC4; Q7L3B7 

Genbank Protein ID

 AC091172; CH471152; BC013742; BC014132; BC016971; BC067788 

Genbank Nucleotide ID

 EAW60771.1; AAH13742.2; AAH14132.2; AAH16971.2; AAH67788.1 

Protein Name

 7-methylguanosine phosphate-specific 5'-nucleotidase 

Protein Synonyms/Alias

 Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein; cN-III-like protein 

Gene Name

 NT5C3B 

Gene Synonyms/Alias

 NT5C3L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
256	KIGFLNDKVEERRER	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. 

Sequence Annotation

 REGION 156 157 Substrate binding (By similarity).
 ACT_SITE 41 41 Nucleophile (By similarity).
 ACT_SITE 43 43 Proton donor (By similarity).
 METAL 41 41 Magnesium (By similarity).
 METAL 43 43 Magnesium; via carbonyl oxygen (By
 METAL 230 230 Magnesium (By similarity).
 BINDING 205 205 Substrate (By similarity).
 MOD_RES 256 256 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008253; F:5'-nucleotidase activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006434; Pyrimidine_nucleotidase_eu. 

Pfam

 PF05822; UMPH-1 

SMART

  

PROSITE

  

PRINTS