CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038773
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 6 
Protein Synonyms/Alias
  
Gene Name
 Dock6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
742GIFPFRLKETVLSEGubiquitination[1]
877SLYLARSKSISSSNPubiquitination[1]
904VSRILASKGVDRSHSubiquitination[1]
923AYAPGGSKAVLRRVPubiquitination[1]
1224AEATVKAKVAELYLPubiquitination[1]
1836DEQEFVYKEPSITKLubiquitination[1]
1935GELAEQHKRKTLLSTacetylation[2]
1937LAEQHKRKTLLSTEHubiquitination[1]
1950EHAFPYIKTRIRVCHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2111 AA 
Protein Sequence
MAASERRAFA HKINRTVAAE VRKQVSRERS GSPHSSRRSS SSLGVPLTEV IEPLDFEDVL 60
LSRPPEVEPG PLRDLIEFPV DDLELLKQPR ECRTTESGVP EDGQLDAQVR AAVEMYSEDW 120
VIVRRRYQHL STAYSPITTE TQREWQKGLT CQVFEQDTPG DERTGPEDVD DPQHCSGSPE 180
DTPRSSGASG IFSLRNLAAD SLLPTLLEQA APEDVDRRNE ALRRQHRAPT LLTLYPAPDE 240
DEAVERCSRP EPPREHFGQR ILVKCLSLKF EIEIEPIFGT LALYDVREKK KISENFYFDL 300
NSDSVKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVV KLEKVLQQGD ISECCEPYMV 360
MKEADTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH LANIVSRPQD RDSDSEGERR 420
PTWAERRRRG PQDRGYSGDD ACSFSSFRPA TLTVTNFFKQ EAERLSDEDL FKFLADMRRP 480
SSLLRRLRPV TAQLKLDISP APENLHFCLS PDLLHVKPYP DPRGRPTKEI LEFPAREVYA 540
PHSCYRNLLF VYPHSLNFSS RQGSVRNLAV RIQYMAGEDQ SQALPVIFGK SSCSEFTREA 600
FTPVVYHNKS PEFYEEFKLR LPACVTENHH LFFTFYHVSC QPRPGTALET PVGFTWIPLL 660
QHGRLRTGPF CLPVSVDQPP PSYSVLTPDV ALPGMRWVDG HKGVFSVELT AVSSVHPQDP 720
HLDKFFTLVH VLEEGIFPFR LKETVLSEGT MEQELRASLA ALRLASPEPL VAFSHLVLDK 780
LVRLVVRPPI ICGQMVNLGR GAFEAMAHVA SLVHRNLEAV QDSRGHCPLL ASYVHYAFRL 840
PGGDLSLPGE APPATVQAAT LARGSGRPAS LYLARSKSIS SSNPDLAVVP GSVDDEVSRI 900
LASKGVDRSH SWVNSAYAPG GSKAVLRRVP PYCGADPRQA IDRNSSRASS YLEASSSALP 960
APQSRHTVQK LLHEELALQW VVSGSAVREL VLQHAWFFFQ LMVKSMELHL LLGQRLDTPR 1020
KLRFPGRFLD DIAALVASVG LEVITRVHKD MKLAERLNAS LAFFLSDLLS IADRGYIFSL 1080
VRAHYKQVAT RLQSAPNPTA LLTLRMDFTR ILCSHEHYVT LNLPCCPLSP PASPSPSVSS 1140
TTSQSSTFSS QAPDPKVTSM FELSGPFRQQ HFLSGLLLTE LALALDPEAE GASLLHKKAI 1200
SAVHSLLCSH DVDSRYAEAT VKAKVAELYL PLLSLARDTL PQLHGFAEGS GQRSRLASML 1260
DSDTEGEGDI GSTINPSVAM AIAGGPLAPG SRTSISQGPS TAARSGCPLS AESSRTLLVC 1320
VLWVLKNAEP TLLQRWAADL ALPQLGRLLD LLYLCLAAFE YKGKKAFERI NSLTFKKSLD 1380
MKARLEEAIL GTIGARQEMV RRSRERSPFG NQENVRWRKS ATHWRQTSDR VDKTKDEMEH 1440
EALVDGNLAT EASLVVLDTL ETIVQTVMLS EARESILSAV LKVVLYSLGS AQSALFLQHG 1500
LATQRALVSK FPELLFEEDT ELCADLCLRL LRHCGSRIST IRMHASASLY LLMRQNFEIG 1560
HNFARVKMLV TMSLSSLVGT TQNFSEEHLR KSLKTILTYA EEDIGLRDST FAEQVQDLMF 1620
NLHMILTDTV KMKEHQEDPE MLMDLMYRIA RGYQGSPDLR LTWLQNMAGK HAELGNHAEA 1680
AQCMVHAAAL VAEYLALLED SRHLPVGCVS FQNVSSNVLE ESAISDDILS PDEEGFCSGK 1740
NFTELGLVGL LEQAAGYFTM GGLYEAVNEV YKNLIPILEA HRDYKKLAAV HGKLQEAFTK 1800
IMHQSSGWER VFGTYFRVGF YGTRFGDLDE QEFVYKEPSI TKLAEISHRL EEFYTERFGD 1860
DVVEIIKDSN PVDKSKLDPQ KAYIQITYVE PHFDTYELKD RVTYFDRNYG LRAFLFCTPF 1920
TPDGRAHGEL AEQHKRKTLL STEHAFPYIK TRIRVCHREE TVLTPVEVAI EDMQKKTREL 1980
AFATEQDPPD AKMLQMVLQG SVGPTVNQGP LEVAQVFLSE IPEDPKLFRH HNKLRLCFKD 2040
FCKKCEDALR KNKALIGPDQ KEYHRELERH YSRLREALQP LLTQRLPQLL APSSTSLRSS 2100
MNRSSFRKAD L 2111 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398 
SMART
  
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2 
PRINTS