| Tag | Content |
|---|
| CPLM ID | CPLM-012484 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 |
Protein Synonyms/Alias | Centaurin-beta-2; Cnt-b2 |
Gene Name | ACAP2 |
Gene Synonyms/Alias | CENTB2; KIAA0041 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | KAFCVANKQFMNGIR | ubiquitination | [1] | | 106 | DQTQRSIKAQLQNFV | ubiquitination | [1] | | 134 | FEKVSEEKENALVKN | ubiquitination | [1] | | 140 | EKENALVKNAQVQRN | ubiquitination | [1] | | 347 | MLQADSEKLRQAWIK | ubiquitination | [1] | | 377 | ESEKLDKKSSPSTGS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). |
Sequence Annotation | DOMAIN 1 226 BAR.
DOMAIN 266 361 PH.
DOMAIN 399 520 Arf-GAP.
REPEAT 640 669 ANK 1.
REPEAT 673 702 ANK 2.
REPEAT 706 735 ANK 3.
ZN_FING 414 437 C4-type.
MOD_RES 384 384 Phosphoserine.
MOD_RES 521 521 Phosphoserine.
MOD_RES 742 742 Phosphotyrosine. |
Keyword | ANK repeat; Coiled coil; Complete proteome; GTPase activation; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 778 AA |
Protein Sequence | MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK AFCVANKQFM 60
NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ TQRSIKAQLQ NFVKEDLRKF 120
KDAKKQFEKV SEEKENALVK NAQVQRNKQH EVEEATNILT ATRKCFRHIA LDYVLQINVL 180
QSKRRSEILK SMLSFMYAHL AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ 240
KHSTIQQKDF SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK 300
KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ AWIKAVQTSI 360
ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES ALQRVQCIPG NASCCDCGLA 420
DPRWASINLG ITLCIECSGI HRSLGVHFSK VRSLTLDTWE PELLKLMCEL GNDVINRVYE 480
ANVEKMGIKK PQPGQRQEKE AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS 540
ISKFGPGDQV RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD 600
SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL GGSLVTCEFL 660
LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ HATDEEGKDP LSIAVEAANA 720
DIVTLLRLAR MNEEMRESEG LYGQPGDETY QDIFRDFSQM ASNNPEKLNR FQQDSQKF 778 |
Gene Ontology | GO:0008060; F:ARF GTPase activator activity; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |