CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026471
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cortactin 
Protein Synonyms/Alias
 Cortactin, isoform CRA_e; Protein Cttn 
Gene Name
 Cttn 
Gene Synonyms/Alias
 rCG_48092 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
226TEKHESQKDYVKGFGacetylation[1]
230ESQKDYVKGFGGKFGacetylation[1]
235YVKGFGGKFGVQTDRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MWKASAGHAV SITQDDGGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE 60
NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG 120
FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG 180
KTEKHESQKD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT 240
DRQDKCALGW DHQEKLQLHE SQKDYAKGFG GKYGVQKDRM DKNASTFEEV VQVPSAYQKT 300
VPIEAVTSKT SNIRANFENL AKEREQEDRR KAEAERAQRM AQERQEQEEA RRKLEEQARA 360
KKQTPPASPS PQPAEDRPPS SPIYEDAAPL KAEPSYGSSE PEPEYSTEAA GLPEASNQQG 420
LAYTSEPVYE TTEVPGHYQA EDDTYDGYES DLGITAIALY DYQAAGDDEI SFDPDDVITN 480
IEMIDDGWWR GVCKGRYGLF PANYVELRQ 509 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:InterPro.
 GO:0001726; C:ruffle; IEA:InterPro.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0006898; P:receptor-mediated endocytosis; IDA:RGD. 
Interpro
 IPR015503; Cortactin.
 IPR003134; Hs1_Cortactin.
 IPR000108; p67phox.
 IPR001452; SH3_domain. 
Pfam
 PF02218; HS1_rep
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS51090; CORTACTIN
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.