CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hematopoietic cell specific Lyn substrate 1 
Protein Synonyms/Alias
 Protein Hcls1; RCG52681 
Gene Name
 Hcls1 
Gene Synonyms/Alias
 rCG_52681 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
41KEQRWGAKTIEGSGRacetylation[1]
69SEEHDILKKRELESGacetylation[1]
109EYVAEVEKHSSQTDAacetylation[1]
118SSQTDAAKGFGGKYGacetylation[1]
123AAKGFGGKYGVERDRacetylation[1]
151VEKHASQKDYSHGFGacetylation[1]
165GGRYGVEKDKRDKAAacetylation[1]
178AALGYDYKGETEKHEacetylation[1]
183DYKGETEKHESQRDYacetylation[1]
192ESQRDYAKGFGGQYGacetylation[1]
202GGQYGIQKDRVDKSAacetylation[1]
223EAPTTAYKKTTPIEAacetylation[1]
241GARGLKAKFESMAEEacetylation[1]
257RKREEEEKAQQMARQacetylation[1]
273QERKAMVKMSREAQQacetylation[1]
296AAPAPLPKKISSEVWacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MWKSVVGHNV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDILKK RELESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120
GGKYGVERDR ADKSAVGFDY KGEVEKHASQ KDYSHGFGGR YGVEKDKRDK AALGYDYKGE 180
TEKHESQRDY AKGFGGQYGI QKDRVDKSAV GFNEMEAPTT AYKKTTPIEA ASSGARGLKA 240
KFESMAEEKR KREEEEKAQQ MARQQQERKA MVKMSREAQQ PSVPVDEPAA PAPLPKKISS 300
EVWPPAESHL PPQSEPVGGR REYPVPSLPT RQPPPQNPLE DNEEPPALPP RTPEGLQVVE 360
EPVYEAAPEP EPEPEPDYED VGELDRPDEE AEGDYEDVLE PEDTPSLSYQ AGHSAGAGGA 420
GISAVALYDY QGEGSDELSF DPDDVITDIE MVDEGWWRGR CHGHFGLFPA NYVKLL 476 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0071345; P:cellular response to cytokine stimulus; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
 GO:2000107; P:negative regulation of leukocyte apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0030854; P:positive regulation of granulocyte differentiation; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0042993; P:positive regulation of transcription factor import into nucleus; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
 GO:0030833; P:regulation of actin filament polymerization; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; ISS:UniProtKB. 
Interpro
 IPR003134; Hs1_Cortactin.
 IPR000108; p67phox.
 IPR001452; SH3_domain. 
Pfam
 PF02218; HS1_rep
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS51090; CORTACTIN
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.