CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007468
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peripherin 
Protein Synonyms/Alias
 Neurofilament 4 
Gene Name
 PRPH 
Gene Synonyms/Alias
 NEF4; PRPH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
229MDEIEFLKKLHEEELacetylation[1]
288QEAEEWYKSKYADLSubiquitination[2]
398IEIATYRKLLEGEESubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Class-III neuronal intermediate filament protein. 
Sequence Annotation
 REGION 1 99 Head.
 REGION 100 405 Rod.
 REGION 100 132 Coil 1A.
 REGION 133 143 Linker 1.
 REGION 144 239 Coil 1B.
 REGION 240 262 Linker 2.
 REGION 263 405 Coil 2.
 REGION 406 470 Tail.
 MOD_RES 17 17 Nitrated tyrosine (By similarity).
 MOD_RES 379 379 Nitrated tyrosine (By similarity).
 MOD_RES 470 470 Phosphotyrosine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Intermediate filament; Nitration; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 470 AA 
Protein Sequence
MSHHPSGLRA GFSSTSYRRT FGPPPSLSPG AFSYSSSSRF SSSRLLGSAS PSSSVRLGSF 60
RSPRAGAGAL LRLPSERLDF SMAEALNQEF LATRSNEKQE LQELNDRFAN FIEKVRFLEQ 120
QNAALRGELS QARGQEPARA DQLCQQELRE LRRELELLGR ERDRVQVERD GLAEDLAALK 180
QRLEEETRKR EDAEHNLVLF RKDVDDATLS RLELERKIES LMDEIEFLKK LHEEELRDLQ 240
VSVESQQVQQ VEVEATVKPE LTAALRDIRA QYESIAAKNL QEAEEWYKSK YADLSDAANR 300
NHEALRQAKQ EMNESRRQIQ SLTCEVDGLR GTNEALLRQL RELEEQFALE AGGYQAGAAR 360
LEEELRQLKE EMARHLREYQ ELLNVKMALD IEIATYRKLL EGEESRISVP VHSFASLNIK 420
TTVPEVEPPQ DSHSRKTVLI KTIETRNGEV VTESQKEQRS ELDKSSAHSY 470 
Gene Ontology
 GO:0044299; C:C-fiber; IEA:Compara.
 GO:0005882; C:intermediate filament; TAS:ProtInc.
 GO:0005883; C:neurofilament; IEA:Compara.
 GO:0042622; C:photoreceptor outer segment membrane; IEA:Compara.
 GO:0005198; F:structural molecule activity; NAS:ProtInc.
 GO:0045104; P:intermediate filament cytoskeleton organization; IEA:Compara. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I. 
Pfam
 PF00038; Filament
 PF04732; Filament_head 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01248; TYPE1KERATIN.