CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022060
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Suppressor of tumorigenicity 7 protein 
Protein Synonyms/Alias
 Protein FAM4A1; Protein HELG 
Gene Name
 ST7 
Gene Synonyms/Alias
 FAM4A1; HELG; RAY1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
377CYTAALLKARAVSDKubiquitination[1, 2]
384KARAVSDKFSPEAASubiquitination[1, 2]
418EFNPHVPKYLLEMKSubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May act as a tumor suppressor. 
Sequence Annotation
 MOD_RES 386 386 Phosphoserine.
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 585 AA 
Protein Sequence
MAEAATGFLE QLKSCIVWSW TYLWTVWFFI VLFLVYILRV PLKINDNLST VSMFLNTLTP 60
KFYVALTGTS SLISGLILIF EWWYFRKYGT SFIEQVSVSH LRPLLGGVDN NSSNNSNSSN 120
GDSDSNRQSV SECKVWRNPL NLFRGAEYNR YTWVTGREPL TYYDMNLSAQ DHQTFFTCDS 180
DHLRPADAIM QKAWRERNPQ ARISAAHEAL EINEIRSRVE VPLIASSTIW EIKLLPKCAT 240
AYILLAEEEA TTIAEAEKLF KQALKAGDGC YRRSQQLQHH GSQYEAQHRR DTNVLVYIKR 300
RLAMCARRLG RTREAVKMMR DLMKEFPLLS MFNIHENLLE ALLELQAYAD VQAVLAKYDD 360
ISLPKSATIC YTAALLKARA VSDKFSPEAA SRRGLSTAEM NAVEAIHRAV EFNPHVPKYL 420
LEMKSLILPP EHILKRGDSE AIAYAFFHLA HWKRVEGALN LLHCTWEGTF RMIPYPLEKG 480
HLFYPYPICT ETADRELLPS FHEVSVYPKK ELPFFILFTA GLCSFTAMLA LLTHQFPELM 540
GVFAKAMIDI FCSAEFRDWN CKSIFMRVED ELEIPPAPQS QHFQN 585 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR007311; ST7.
 IPR011990; TPR-like_helical. 
Pfam
 PF04184; ST7 
SMART
  
PROSITE
  
PRINTS