CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015360
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatase and actin regulator 3 
Protein Synonyms/Alias
 Scaffold-associated PP1-inhibiting protein; Scapinin 
Gene Name
 Phactr3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
43PWKWRKKKNEKLKQTacetylation[1]
46WRKKKNEKLKQTTSAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 REPEAT 52 77 RPEL 1.
 REPEAT 359 384 RPEL 2.
 REPEAT 397 422 RPEL 3.
 REPEAT 435 460 RPEL 4.
 MOD_RES 29 29 Phosphothreonine (By similarity).  
Keyword
 Actin-binding; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 517 AA 
Protein Sequence
MDQTPPARSE PLVSGIRTPP VRRNSKLATL GRIFKPWKWR KKKNEKLKQT TSALEKKMAG 60
RQGREELIKQ GLLEMMEQDS ESKACSPKEG SQPAQSEPSA GEQETLTSEG VQPGSPSASG 120
TDQASQDELL SSDAHPDDTA KMSSASSGEE ADAGNLLPTT DEPSQEALSG SLDSPPRTLE 180
RSASQLPSPP LLPTPPPKAS SKATKNVTGQ AALFQGSSMK NNEPVLRGQL PTPTGSPHLT 240
TVHRPLPPSR VIEELHRALA TKHRQDSFQG RECRGSPKKR MDVRLSRTSS MERGKERDEA 300
WSFDGASENK WTAAKDSEEN KENLILSSEL KDDLLLYQDE EALNDSIISG TLPRKCKKEL 360
LAVKLRNRPS KQELEDRNIF PRRTDEERQE IRQQIEMKLS KRLSQRPAVE ELERRNILKQ 420
RNDQTEQEER REIKQRLTRK LNQRPTVDEL RDRKILIRFS DYVEVARAQD YDRRADKPWT 480
RLSAADKAAI RKELNEYKSN EMEVHASSKH LTRFHRP 517 
Gene Ontology
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:RGD.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0004864; F:protein phosphatase inhibitor activity; TAS:RGD. 
Interpro
 IPR004018; RPEL_repeat. 
Pfam
 PF02755; RPEL 
SMART
 SM00707; RPEL 
PROSITE
 PS51073; RPEL 
PRINTS