UniProt Accession

 NDRG1_RAT; Q6JE36 

Genbank Protein ID

 AY500369; BC081898 

Genbank Nucleotide ID

 AAS78638.1; AAH81898.1 

Protein Name

 Protein NDRG1 

Protein Synonyms/Alias

 N-myc downstream-regulated gene 1 protein; Protein Ndr1 

Gene Name

 Ndrg1 

Gene Synonyms/Alias

 Ndr1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
14	DVDLAEVKPLVEKGE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). 

Sequence Annotation

 REPEAT 339 348 1.
 REPEAT 349 358 2.
 REPEAT 359 368 3.
 REGION 339 368 3 X 10 AA tandem repeats of G-[PST]-R-S-
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).
 MOD_RES 328 328 Phosphothreonine; by SGK1 (By
 MOD_RES 330 330 Phosphoserine; by SGK1 (By similarity).
 MOD_RES 332 332 Phosphoserine; by SGK1 (By similarity).
 MOD_RES 333 333 Phosphoserine (By similarity).
 MOD_RES 335 335 Phosphothreonine (By similarity).
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 346 346 Phosphothreonine; by SGK1 (By
 MOD_RES 356 356 Phosphothreonine; by SGK1 (By
 MOD_RES 362 362 Phosphoserine (By similarity).
 MOD_RES 364 364 Phosphoserine (By similarity).
 MOD_RES 366 366 Phosphothreonine; by SGK1 (By
 MOD_RES 375 375 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Microtubule; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0055038; C:recycling endosome membrane; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0045576; P:mast cell activation; IEA:Compara.
 GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Compara.
 GO:0090232; P:positive regulation of spindle checkpoint; IEA:Compara. 

Interpro

 IPR004142; Ndr. 

Pfam

 PF03096; Ndr 

SMART

  

PROSITE

  

PRINTS