CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001533
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin conjugation factor E4 B 
Protein Synonyms/Alias
 Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2 
Gene Name
 UBE4B 
Gene Synonyms/Alias
 HDNB1; KIAA0684; UFD2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
665NRTVEDLKNNESQWKubiquitination[1]
672KNNESQWKDSPLATRubiquitination[1]
822AVQPRTQKFFEMIENubiquitination[1]
929VQEEMKNKEQWDQLPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity). 
Sequence Annotation
 DOMAIN 1231 1293 U-box.
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 84 84 Phosphoserine.
 MOD_RES 88 88 Phosphoserine.
 MOD_RES 90 90 Phosphoserine.
 MOD_RES 101 101 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 803 803 Phosphoserine.
 MOD_RES 1265 1265 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1302 AA 
Protein Sequence
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 60
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 120
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL 180
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD 240
RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LGASGGASNW DSYSDHFTIE TCKETDMLNY 300
LIECFDRVGI EEKKAPKMCS QPAVSQLLSN IRSQCISHTA LVLQGSLTQP RSLQQPSFLV 360
PYMLCRNLPY GFIQELVRTT HQDEEVFKQI FIPILQGLAL AAKECSLDSD YFKYPLMALG 420
ELCETKFGKT HPVCNLVASL RLWLPKSLSP GCGRELQRLS YLGAFFSFSV FAEDDVKVVE 480
KYFSGPAITL ENTRVVSQSL QHYLELGRQE LFKILHSILL NGETREAALS YMAAVVNANM 540
KKAQMQTDDR LVSTDGFMLN FLWVLQQLST KIKLETVDPT YIFHPRCRIT LPNDETRVNA 600
TMEDVNDWLT ELYGDQPPFS EPKFPTECFF LTLHAHHLSI LPSCRRYIRR LRAIRELNRT 660
VEDLKNNESQ WKDSPLATRH REMLKRCKTQ LKKLVRCKAC ADAGLLDESF LRRCLNFYGL 720
LIQLLLRILD PAYPDITLPL NSDVPKVFAA LPEFYVEDVA EFLFFIVQYS PQALYEPCTQ 780
DIVMFLVVML CNQNYIRNPY LVAKLVEVMF MTNPAVQPRT QKFFEMIENH PLSTKLLVPS 840
LMKFYTDVEH TGATSEFYDK FTIRYHISTI FKSLWQNIAH HGTFMEEFNS GKQFVRYINM 900
LINDTTFLLD ESLESLKRIH EVQEEMKNKE QWDQLPRDQQ QARQSQLAQD ERVSRSYLAL 960
ATETVDMFHI LTKQVQKPFL RPELGPRLAA MLNFNLQQLC GPKCRDLKVE NPEKYGFEPK 1020
KLLDQLTDIY LQLDCARFAK AIADDQRSYS KELFEEVISK MRKAGIKSTI AIEKFKLLAE 1080
KVEEIVAKNA RAEIDYSDAP DEFRDPLMDT LMTDPVRLPS GTIMDRSIIL RHLLNSPTDP 1140
FNRQTLTESM LEPVPELKEQ IQAWMREKQN SDH 1173 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0000151; C:ubiquitin ligase complex; TAS:UniProtKB.
 GO:0019899; F:enzyme binding; ISS:UniProtKB.
 GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:Compara.
 GO:0008626; P:granzyme-mediated apoptotic signaling pathway; IDA:UniProtKB.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0000209; P:protein polyubiquitination; IEA:Compara.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; TAS:UniProtKB.
 GO:0034976; P:response to endoplasmic reticulum stress; IEA:Compara.
 GO:0009411; P:response to UV; IDA:UniProtKB.
 GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Compara. 
Interpro
 IPR019474; Ub_conjug_fac_E4_core.
 IPR003613; Ubox_domain.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF04564; U-box
 PF10408; Ufd2P_core 
SMART
 SM00504; Ubox 
PROSITE
  
PRINTS