| Tag | Content |
|---|
| CPLM ID | CPLM-001078 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | H(+)/Cl(-) exchange transporter 7 |
Protein Synonyms/Alias | Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7 |
Gene Name | Clcn7 |
Gene Synonyms/Alias | Clc7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 79 | DPPHTFPKEIPHNEK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. |
Sequence Annotation | DOMAIN 629 693 CBS 1.
DOMAIN 739 797 CBS 2.
NP_BIND 656 658 ATP (By similarity).
NP_BIND 781 784 ATP (By similarity).
MOTIF 201 205 Selectivity filter part_1 (By
MOTIF 243 247 Selectivity filter part_2 (By
MOTIF 510 514 Selectivity filter part_3 (By
BINDING 202 202 Chloride (By similarity).
BINDING 512 512 Chloride; via amide nitrogen (By
BINDING 600 600 Chloride (By similarity). |
Keyword | Antiport; ATP-binding; CBS domain; Chloride; Complete proteome; Ion transport; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 803 AA |
Protein Sequence | MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA LFRIGQMNNV 60
ELDDELLDPE VDPPHTFPKE IPHNEKLLSL KYESLDYDNS ENQLFLEEER RINHTAFRTV 120
EIKRWVICAL IGILTGLVAC FIDIVVENLA GLKYRVIKDN IDKFTEKGGL SFSLLLWATL 180
NSAFVLVGSV IVAFIEPVAA GSGIPQIKCF LNGVKIPHVV RLKTLVIKVS GVILSVVGGL 240
AVGKEGPMIH SGSVIAAGIS QGRSTSLKRD FKIFEYFRRD TEKRDFVSAG AAAGVSAAFG 300
APVGGVLFSL EEGASFWNQF LTWRIFFASM ISTFTLNFVL SIYHGNMWDL SSPGLINFGR 360
FDSEKMAYTI HEIPVFIAMG VVGGILGAVF NALNYWLTMF RIRYIHRPCL QVIEAMLVAA 420
VTATVAFVLI YSSRDCQPLQ GSSMSYPLQL FCADGEYNSM AAAFFNTPEK SVVSLFHDPP 480
GSYNPMTLGL FTLVYFFLAC WTYGLTVSAG VFIPSLLIGA AWGRLFGISL SYLTGAAIWA 540
DPGKYALMGA AAQLGGIVRM TLSLTVIMME ATSNVTYGFP IMLVLMTAKI VGDVFIEGLY 600
DMHIQLQSVP FLHWEAPVTS HSLTAREVMS TPVTCLRRRE KVGIIVDVLS DTASNHNGFP 660
VVEDVGDTQP ARLQGLILRS QLIVLLKHKV FVERSNMGLV QRRLRLKDFR DAYPRFPPIQ 720
SIHVSQDERE CTMDLSEFMN PSPYTVPQEA SLPRVFKLFR ALGLRHLVVV DNHNQVVGLV 780
TRKDLARYRL GKGGLEELSL AQT 803 |
Gene Ontology | GO:0031410; C:cytoplasmic vesicle; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. GO:0015297; F:antiporter activity; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. GO:0009268; P:response to pH; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |