CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024225
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 1 
Protein Synonyms/Alias
 GroEL protein 1; Protein Cpn60 1 
Gene Name
 groL1 
Gene Synonyms/Alias
 groEL1; groL2; MSMEG_0880; MSMEI_0859 
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
116GANPLGLKRGIEKAVpupylation[1]
132KVTETLLKSAKEVETpupylation[2]
Reference
 [1] Proteome-wide identification of mycobacterial pupylation targets.
 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH.
 Mol Syst Biol. 2010 Jul 13;6:386. [PMID: 20631680]
 [2] Expansion of the mycobacterial "PUPylome".
 Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
 Mol Biosyst. 2010 Feb;6(2):376-85. [PMID: 20094657] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
 CROSSLNK 132 132 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Isopeptide bond; Nucleotide-binding; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MAKTIAYDEE ARRGLERGLN SLADAVKVTL GPKGRNVVLE KKWGAPTITN DGVSIAKEIE 60
LEDPYEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVR EGLRNVAAGA NPLGLKRGIE 120
KAVEKVTETL LKSAKEVETK EQIAATAGIS AGDQSIGDLI AEAMDKVGNE GVITVEESNT 180
FGLQLELTEG MRFDKGYISG YFVTDAERQE AVLEDPYILL VSSKVSTVKD LLPLLEKVIQ 240
SGKPLLIIAE DVEGEALSTL VVNKIRGTFK SVAVKAPGFG DRRKAMLQDM AILTGGQVIS 300
EEVGLSLETA DVSLLGKARK VVVTKDETTI VEGAGDAEAI QGRVAQIRAE IENSDSDYDR 360
EKLQERLAKL AGGVAVIKAG AATEVELKER KHRIEDAVRN AKAAVEEGIV AGGGVALLQS 420
APSLEELSLT GDEATGANIV RVALSAPLKQ IALNGGLEPG VVAEKVSNLP AGHGLNAATG 480
EYEDLLAAGV ADPVKVTRSA LQNAASIAAL FLTTEAVVAD KPEKAAAPAG DPTGGMGGMD 540
F 541 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.