CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell CLL/lymphoma 9-like protein 
Protein Synonyms/Alias
 B-cell lymphoma 9-like protein; BCL9-like protein; BCL9-related beta-catenin-binding protein; Protein BCL9-2 
Gene Name
 Bcl9l 
Gene Synonyms/Alias
 B9l 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36HCPPAPAKPMHPENKacetylation[1, 2, 3]
108VSPFSSLKGKVKRERacetylation[1, 2, 4]
110PFSSLKGKVKRERSVacetylation[2, 4]
137PSLDSEAKEVAPRSKacetylation[1, 2, 4]
1329SRIIPSEKPSSTLQYacetylation[2, 4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. 
Sequence Annotation
 REGION 302 530 Necessary for interaction with CTNNB1.
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 36 36 N6-acetyllysine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 108 108 N6-acetyllysine (By similarity).
 MOD_RES 116 116 Phosphoserine (By similarity).
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 137 137 N6-acetyllysine (By similarity).
 MOD_RES 747 747 Phosphoserine (By similarity).
 MOD_RES 810 810 Phosphoserine (By similarity).
 MOD_RES 912 912 Phosphoserine (By similarity).
 MOD_RES 972 972 Phosphoserine (By similarity).
 MOD_RES 984 984 Phosphoserine.
 MOD_RES 994 994 Phosphoserine.
 MOD_RES 1001 1001 Phosphoserine.
 MOD_RES 1007 1007 Phosphoserine.
 MOD_RES 1014 1014 Phosphoserine (By similarity).  
Keyword
 Acetylation; Activator; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1494 AA 
Protein Sequence
MRILANKTRL PHPRRREAPG SPPLSPRGHC PPAPAKPMHP ENKLTNHGKT GNGGAQSQHQ 60
NVNQGPTCNL GSKGVGAGSH GAKANQISPS NSSLKNPQAG VSPFSSLKGK VKRERSVSVD 120
SGEQREAGTP SLDSEAKEVA PRSKRRCVLE RKQPYSGDEW CSGPDSEEDD KPIAAAHNCN 180
VADPAMVTPQ LGPGQTAQLP LSESSAPGPQ HGPQPGLRPD VPGGGGGGVP GKPPSQFVYV 240
FTTHLANTAA EAVLQGRAES ILAYHQQNVP RAKLDQAPKV PPTPEPLPLN TPSAGTPQSQ 300
PPPLPPPPPA PGSAPPALPP EGPPEDTSQD LAPNSVGAAS TGGGTGGTHP NTPTAATANN 360
PLPPGGDPGS APGSALLGEA TPTGNGQRNL VGSEGLSKEQ LEHRERSLQT LRDIERLLLR 420
SGETEPFLKG PPGGAGEGGP PAQAPSAAQP PPSAPPGGLK KYEEPLQSMI SQTQSLGGPP 480
LEHEVPGHPQ GGDMGQQMNM MMQRLGQDSL TPEQVAWRKL QEEYYEEKRR KEEQIGLHGG 540
RPLQDMVGMG GMMGRGPPPP YHSKPGDQWP PGMGAQLRGP MDVQDPMQLR PGPPFPGPRF 600
PGNQMQRVPG FGGMQSMPME VPMNAMQRPV RPGMAWNEDL PPIGGPSNFA QNAVPYPGGQ 660
GEAERFMTPR VREELLRHQL LEKRSMGMQR PLGMAGSGMG QSMEMERMIQ AHRQMDPAMF 720
PGQMTGGDGL AGTPMGIEFG GGRGLLSPPM GQSGLREVDP PMGPGNLNMN MNVNMNMNMN 780
LNVQMTPQQQ MLMSQKMRGP GDMMGPQGLS PEEMARVRAQ NSSGMMGGPQ KMLMPSQFPN 840
QGQQGFSGGQ GPYQAMPQDM GNTPDMFSPD QSSVPMGTVG TARLSHMPLP PASNPPGSVH 900
LASNRGLGRR PSDLTISINQ MGSPGMGHLK SPTLSQVHSP LVTSPSANLK SPQTPSQMVP 960
LPSANPPGPL KSPQVLSSSL GVRSPTGSPS RLKSPSMAVP SPGWVASPKT AMPSPGVSQN 1020
KQPPLSINSS STLGNVEQGA LPPSAPRNSS SAPPANPSSG LMNPSLPFTS SPDPTPSQNP 1080
LSLMMSQMSK YAMPSSTPLY HNAIKTIATS DDELLPDRPL LPPPPPPQGS GPGISNNQPN 1140
QMHMNPAAAQ SPMGMNLPGQ QPLSHEPPPT MLPSPTPLGS NIPLHPNAQG TGGSSQNSMM 1200
MAPGGPDSLN APCGPVPSSS QMMSFPPRLQ QPHGAMAPTG AGGPGLQQHY PSGMALPPED 1260
LPTQPPGPIP PQQHLMGKGM TGRMGDAYPP GVLPGVASVL NDPELSEVIR PTPTGIPEFD 1320
LSRIIPSEKP SSTLQYFPKS ENQPPKAQPP NLHLMNLQNM MAEQTPSRPP NLPGQQGVQR 1380
GLSMSMCHPG QMSLLGRTGV PPQQGMVPHG LHQGVMSPPQ GLMTQQNFML MKQRGVGGEV 1440
YTQPPHMLSP QGSLMGPPPQ QNLMVSHPLR QRSVSLDSQM GYLPTPGSMA NLPF 1494 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IGI:MGI.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0035914; P:skeletal muscle cell differentiation; IGI:MGI.
 GO:0035019; P:somatic stem cell maintenance; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR015668; Bcl-9.
 IPR024670; BCL9_beta-catenin-bd_dom. 
Pfam
 PF11502; BCL9 
SMART
  
PROSITE
  
PRINTS