UniProt Accession

 CDK20_HUMAN; Q8IZL9; A2A389; A2A390; B4DQX1; O95137; Q5EDC4; Q5VYW1; Q9BUF4 

Genbank Protein ID

 AF035013; AF113130; AY904367; AF547664; AK075325; AK298993; AL353572; AL353572; AL353572; CH471089; CH471089; BC002655 

Genbank Nucleotide ID

 AAC98920.1; AAF43778.1; AAW82349.1; AAN28684.1; BAG52110.1; BAG61083.1; CAH72843.1; CAM17657.1; CAM17658.1; EAW62746.1; EAW62748.1; AAH02655.1 

Protein Name

 Cyclin-dependent kinase 20 

Protein Synonyms/Alias

 CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42 

Gene Name

 CDK20 

Gene Synonyms/Alias

 CCRK; CDCH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	GAHGIVFKAKHVETG	ubiquitination	[1]
22	HGIVFKAKHVETGEI	ubiquitination	[2]
33	TGEIVALKKVALRRL	ubiquitination	[3]
34	GEIVALKKVALRRLE	ubiquitination	[2]
53	NQALREIKALQEMED	ubiquitination	[2, 3]
129	NIVHRDLKPANLLIS	ubiquitination	[2, 3]
239	TELPDYNKISFKEQV	ubiquitination	[3]
281	HQRIAASKALLHQYF	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. 

Sequence Annotation

 DOMAIN 4 288 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 ACT_SITE 127 127 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Cell cycle; Cell division; Cell projection; Cilium; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS