CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011872
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein LDB19 
Protein Synonyms/Alias
 Low dye-binding protein 19 
Gene Name
 LDB19 
Gene Synonyms/Alias
 YOR322C; O6152 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
75SAEDKSLKNTESNVSubiquitination[1]
463QQLQQELKNNSSLFTubiquitination[1]
486GEMKSGWKTDFDNNGubiquitination[1, 2, 3, 4]
634NHSTNKEKASNGASNubiquitination[1]
703INNGIKNKLYSTMSTubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
 Hitchcock AL, Auld K, Gygi SP, Silver PA.
 Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12735-40. [PMID: 14557538]
 [3] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [4] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface. Involved in the resistance to EDTA, cadmium chloride, cycloheximide, 6-dimethylaminopurine, methyl caffeate, beta-chloro-L-alanine, caffeine and cerulenin. 
Sequence Annotation
 MOD_RES 93 93 Phosphothreonine.
 MOD_RES 384 384 Phosphoserine.
 MOD_RES 619 619 Phosphothreonine.
 MOD_RES 808 808 Phosphoserine.
 CROSSLNK 486 486 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cell cycle; Complete proteome; Cytoplasm; Golgi apparatus; Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 818 AA 
Protein Sequence
MAFSRLTSTH QSNHNGYSNS NKKGQSLPLT LSIDVESPPC VLYGSAMESS GAVLSGLFTV 60
TVVDPYSSAE DKSLKNTESN VSTTSKSLKR KSTFGSALSS RLSSLSASTS NISPSTSSTS 120
ISHSPTPANL RIMAGYTKIT ITSVTLSLVQ KIHFHKPFVP NISSMQTCMN CKTKITNMKS 180
WEIQSNTQDL SVGSHSYPFS YLIPGSVPCS SSLGATAETQ VKYELIAVVT YIDPHRNSFS 240
SGHSTPRKEG SSSKKRLLQL AMPIAVTRSI PRGPDKNSLR VFPPTELTAA AVLPNVVYPK 300
STFPLEMKLD GVSSGDRRWR MRKLSWRIEE TTRVKAHACP VHKHELRQLE EQVKIKESEK 360
SKKPRSHIKR YGELGPQIRV AVNSLENMPS QRLPGEPGRE QAPNSSGPAS TGNVGLDDEN 420
PVNEDEEDQP GSEFIHPSDD ALRQELLMQQ QRARQQQLQQ ELKNNSSLFT EEVRIISKGE 480
MKSGWKTDFD NNGKIELVTE IDCMGLNSGV SNPVMHASTL QTPSTGNKKP SINVACDIQD 540
PNLGLYVSHI LAVEIVVAEE TLQYANGQPI RKPNSKNKKE TNNNTMNVHN PDQRLAELSP 600
IFANRNTPKV RRMGPEDITP VNSNKSNHST NKEKASNGAS NSNIVSVPTG AARVLRMQFR 660
LTVTERSGLG ISWDEEVPPI YQDVELLSPP CYELSINNGI KNKLYSTMST PVRSEDDFVG 720
GSDEDIGNYE SQGLEPGPNV QEVTITQNKL TIPPTAHHYQ PASSSQRSLT TVQSPPLESV 780
VSVQGSVPFR GHVLTPHSTR DIRIQNFSDF LDSNRITQ 818 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005794; C:Golgi apparatus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0070086; P:ubiquitin-dependent endocytosis; IMP:SGD. 
Interpro
 IPR024391; LDB19_N. 
Pfam
 PF13002; LDB19 
SMART
  
PROSITE
  
PRINTS