CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029692
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 
Protein Synonyms/Alias
  
Gene Name
 Pik3cd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
995SKDIQYLKDSLALGKubiquitination[1]
1014ALKHFRVKFNEALREacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1040 AA 
Protein Sequence
MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH 60
MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL 120
IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPLQ LEPSARGWRA 180
GLLRVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA 240
LQVNGRHEYL YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 300
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK AGLFHGNEML CKTVSSSEVN 360
VCSEPVWKQR LEFDISVCDL PRMARLCFAL YAVVEKAKKA RSTKKKSKKA DCPIAWANLM 420
LFDYKDQLKT GERCLYMWPS VPDEKGELLN PAGTVRGNPN TESAAALVIY LPEVAPHPVY 480
FPALEKILEL GRHGERGRIT EEEQLQLREI LERRGSGELY EHEKDLVWKM RHEVQEHFPE 540
ALARLLLVTK WNKHEDVAQM LYLLCSWPEL PVLSALELLD FSFPDCYVGS FAIKSLRKLT 600
DDELFQYLLQ LVQVLKYESY LDCELTKFLL GRALANRKIG HFLFWHLRSE MHVPSVALRF 660
GLIMEAYCRG STHHMKVLMK QGEALSKLKA LNDFVKVSSQ KTTKPQTKEM MHMCMRQETY 720
MEALSHLQSP LDPSTLLEEV CVEQCTFMDS KMKPLWIMYS SEEAGSAGNV GIIFKNGDDL 780
RQDMLTLQMI QLMDVLWKQE GLDLRMTPYG CLPTGDRTGL IEVVLHSDTI ANIQLNKSNM 840
AATAAFNKDA LLNWLKSKNP GEALDRAIEE FTLSCAGYCV ATYVLGIGDR HSDNIMIRES 900
GQLFHIDFGH FLGNFKTKFG INRERVPFIL TYDFVHVIQQ GKTNNSEKFE RFRGYCERAY 960
TILRRHGLLF LHLFALMRAA GLPELSCSKD IQYLKDSLAL GKTEEEALKH FRVKFNEALR 1020
ESWKTKVNWL AHNVSKDNRQ 1040 
Gene Ontology
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IBA:RefGenome.
 GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IBA:RefGenome.
 GO:0042113; P:B cell activation; IMP:MGI.
 GO:0001782; P:B cell homeostasis; IMP:MGI.
 GO:0007166; P:cell surface receptor signaling pathway; IMP:MGI.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR003113; PI3K_adapt-bd_dom.
 IPR002420; PI3K_C2_dom.
 IPR000341; PI3K_Ras-bd_dom.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00792; PI3K_C2
 PF02192; PI3K_p85B
 PF00794; PI3K_rbd
 PF00613; PI3Ka 
SMART
 SM00142; PI3K_C2
 SM00143; PI3K_p85B
 SM00144; PI3K_rbd
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51544; PI3K_ABD
 PS51547; PI3K_C2
 PS51546; PI3K_RBD
 PS51545; PIK_HELICAL 
PRINTS