CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031436
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone deacetylase 6 
Protein Synonyms/Alias
 cDNA FLJ56474, highly similar to Histone deacetylase 6 
Gene Name
 HDAC6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
863REGPSSSKLVTKKAPubiquitination[1]
887RMTTREKKVLEAGMGacetylation[2]
895VLEAGMGKVTSASFGacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1229 AA 
Protein Sequence
MSGANRGRGQ ASSTMTSTGQ DSTTTRQRRS RQNPQSPPQD SSVTSKRNIK KGAVPRSIPN 60
LAEVKKKGKM KKLGQAMEED LIVGLQGMDL NLEAEALAGT GLVLDEQLNE FHCLWDDSFP 120
EGPERLHAIK EQLIQEGLLD RCVSFQARFA EKEELMLVHS LEYIDLMETT QYMNEGELRV 180
LADTYDSVYL HPNSYSCACL ASGSVLRLVD AVLGAEIRNG MAIIRPPGHH AQHSLMDGYC 240
MFNHVAVAAR YAQQKHRIRR VLIVDWDVHH GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH 300
LKASNWSTTG FGQGQGYTIN VPWNQVGMRD ADYIAAFLHV LLPVALEFQP QLVLVAAGFD 360
ALQGDPKGEM AATPAGFAQL THLLMGLAGG KLILSLEGGY NLRALAEGVS ASLHTLLGDP 420
CPMLESPGAP CRSAQASVSC ALEALEPFWE VLVRSTETVE RDNMEEDNVE ESEEEGPWEP 480
PVLPILTWPV LQSRTGLVYD QNMMNHCNLW DSHHPEVPQR ILRIMCRLEE LGLAGRCLTL 540
TPRPATEAEL LTCHSAEYVG HLRATEKMKT RELHRESSNF DSIYICPSTF ACAQLATGAA 600
CRLVEAVLSG EVLNGAAVVR PPGHHAEQDA ACGFCFFNSV AVAARHAQTI SGHALRILIV 660
DWDVHHGNGT QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG ASSQIGRAAG TGFTVNVAWN 720
GPRMGDADYL AAWHRLVLPI AYEFNPELVL VSAGFDAARG DPLGGCQVSP EGYAHLTHLL 780
MGLASGRIIL ILEGGYNLTS ISESMAACTR SLLGDPPPLL TLPRPPLSGA LASITETIQV 840
HRRYWRSLRV MKVEDREGPS SSKLVTKKAP QPAKPRLAER MTTREKKVLE AGMGKVTSAS 900
FGEESTPGQT NSETAVVALT QDQPSEAATG GATLAQTISE AAIGGAMLGQ TTSEEAVGGA 960
TPDQTTSEET VGGAILDQTT SEDAVGGATL GQTTSEEAVG GATLAQTTSE AAMEGATLDQ 1020
TTSEEAPGGT ELIQTPLASS TDHQTPPTSP VQGTTPQISP STLIGSLRTL ELGSESQGAS 1080
ESQAPGEENL LGEAAGGQDM ADSMLMQGSR GLTDQAIFYA VTPLPWCPHL VAVCPIPAAG 1140
LDVTQPCGDC GTIQENWVCL SCYQVYCGRY INGHMLQHHG NSGHPLVLSY IDLSAWCYYC 1200
QAYVHHQALL DVKNIAHQNK FGEDMPHPH 1229 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR001607; Znf_UBP. 
Pfam
 PF00850; Hist_deacetyl
 PF02148; zf-UBP 
SMART
 SM00290; ZnF_UBP 
PROSITE
 PS50271; ZF_UBP 
PRINTS
 PR01270; HDASUPER.