UniProt Accession

 F6Y6L6_MOUSE; F6Y6L6 

Genbank Protein ID

 AC034099 

Genbank Nucleotide ID

  

Protein Name

 Cathepsin D 

Protein Synonyms/Alias

  

Gene Name

 Ctsd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	ARGIKVEKQIFGEAT	acetylation	[1]
43	ARGIKVEKQIFGEAT	ubiquitination	[2]
51	QIFGEATKQPGIVFV	acetylation	[1]
51	QIFGEATKQPGIVFV	ubiquitination	[2]
93	MQQKLVDKNIFSFYL	acetylation	[1]
134	SYLNVTRKAYWQVHM	acetylation	[1]
198	EYMIPCEKVSSLPTV	acetylation	[3]
208	SLPTVYLKLGGKNYE	acetylation	[1]
208	SLPTVYLKLGGKNYE	ubiquitination	[2]
220	NYELHPDKYILKAQG	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aspartyl protease; Complete proteome; Hydrolase; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004190; F:aspartic-type endopeptidase activity; IDA:MGI.
 GO:0000045; P:autophagic vacuole assembly; IMP:MGI.
 GO:0006508; P:proteolysis; IC:MGI. 

Interpro

 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS. 

Pfam

 PF00026; Asp 

SMART

  

PROSITE

 PS00141; ASP_PROTEASE 

PRINTS

 PR00792; PEPSIN.