UniProt Accession

 IRK8_MOUSE; P97794 

Genbank Protein ID

 D88159; BC003756 

Genbank Nucleotide ID

 BAA13550.1; AAH03756.1 

Protein Name

 ATP-sensitive inward rectifier potassium channel 8 

Protein Synonyms/Alias

 Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1 

Gene Name

 Kcnj8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MLARKSIIPEEY	ubiquitination	[1]
361	SARELDEKPSILIQT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). 

Sequence Annotation

 MOTIF 140 145 Selectivity filter (By similarity).  

Keyword

 Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0008282; C:ATP-sensitive potassium channel complex; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030016; C:myofibril; IDA:MGI.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IEA:Compara.
 GO:0051607; P:defense response to virus; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0010107; P:potassium ion import; IEA:Compara.
 GO:0043330; P:response to exogenous dsRNA; IMP:MGI.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
 GO:0009268; P:response to pH; IEA:Compara.
 GO:0042311; P:vasodilation; IEA:Compara. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003278; K_chnl_inward-rec_Kir6.1.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01331; KIR61CHANNEL.
 PR01320; KIRCHANNEL.