CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 8 
Protein Synonyms/Alias
  
Gene Name
 Usp8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
136VRKQLEEKDRREEEQacetylation[1]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1091 AA 
Protein Sequence
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK TSTKNTKFCK FSSFLSYIHS AQKIFKTAEE 60
CRLDRDEERA YVLYMKYVAV YNLIKKRPDF KQQQDYYLSI LGPANIKKAI EEAERLSESL 120
KLRYEEAEVR KQLEEKDRRE EEQLQQQKRQ EMGREDSGAA AKRSVENLLD SKTKTQRING 180
EKSEGAAAAE RGAITAKELY TMMMDKNTSL IIMDARKIQD YQHSCILDSL SVPEEAISPG 240
VTASWIEANL SDDSKDTWKK RGSVDYVVLL DWFSSAKDLL LGTTLRSLKD ALFKWESKTV 300
LRHEPLVLEG GYENWLLCYP QFTTNAKVTP PPRSRAEEVS VSLDFTYPSL EEPVPSKLPT 360
QMPPPPIETN EKALLVTDQD EKLRLSTQPA LAGPGAAPRA EASPIIQPAP ATKSVPQVDR 420
TKKPSVKLPE DHRIKSENTD QSGRVLSDRS TKPVFPSPTT MLTDEEKARI HQETALLMEK 480
NKQEKELWDK QQKEQKEKLR REEQERKAGK TQDADERDST ENQHKAKDGQ EKKDSKQTKT 540
EDRELSADGA QEATGTQRQS KSEHEASDAK VPVEGKRCPT SEAQKRPADV SPASVSGELN 600
AGKAQREPLT RARSEEMGRI VPGLPLGWAK FLDPITGTFR YYHSPTNTVH MYPPEMAPSS 660
APPSTPPTHK VKPQVPAERD REPSKLKRSY SSPDITQALQ EEEKRRPAVT PMVNRENKPP 720
CYPKAEISRL SASQIRNLNP VFGGSGPALT GLRNLGNTCY MNSILQCLCN APHLADYFNR 780
NCYQDDINRS NLLGHKGEVA EEFGIIMKAL WTGQYRYISP KDFKVTIGKI NDQFAGSSQQ 840
DSQELLLFLM DGLHEDLNKA DNRKRHKEEN NEHLDDLQAA EHAWQKHKQL NESIIVALFQ 900
GQFKSTVQCL TCRRRSRTFE AFMYLSLPLA STSKCTLQDC LRLFSKEEKL TDNNRFYCSH 960
CRARRDSLKK IEIWKLPPVL LVHLKRFSYD GRWKQKLQTS VDFPLENLDL SQYVIGPKNS 1020
LKKYNLFSVS NHYGGLDGGH YTAYCKNAAR QRWFKFDDHE VSDISVSSVR SSAAYILFYT 1080
SLGPRITDVA T 1091 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0005622; C:intracellular; IDA:MGI.
 GO:0030496; C:midbody; IDA:MGI.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IDA:MGI.
 GO:0007032; P:endosome organization; IEA:Compara.
 GO:0000281; P:mitotic cytokinesis; IEA:Compara.
 GO:0016579; P:protein deubiquitination; IDA:MGI.
 GO:0071108; P:protein K48-linked deubiquitination; IEA:Compara.
 GO:0070536; P:protein K63-linked deubiquitination; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IPI:MGI.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR015063; DUF1873.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR001763; Rhodanese-like_dom. 
Pfam
 PF08969; DUF1873
 PF00581; Rhodanese
 PF00443; UCH 
SMART
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS