CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017086
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angiomotin-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 AMOTL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
195LPTYEEAKAQSQFFRubiquitination[1, 2]
227MAGGTSQKSRTEGRPubiquitination[1, 2]
289SGNGKGFKVGGGPSPubiquitination[2]
302SPAQPAGKVLDPRGPubiquitination[2, 3]
318PEYPFKTKQMMSPVSubiquitination[2]
347GMLHEMVKPYPAPQPubiquitination[2]
471DNADKLHKFEKELQRubiquitination[2]
474DKLHKFEKELQRISEubiquitination[2]
503LDKAMRNKLEGEIRRubiquitination[2]
540EYEGHEDKAAEGHYAubiquitination[2]
551GHYASQNKEFLKEKEubiquitination[1, 2]
594NAQARVIKLEEELREubiquitination[2, 4]
625QLQSACEKREQMERRubiquitination[2]
649DALRTQQKHGNGQPAubiquitination[2]
686ALEADMTKWEQKYLEubiquitination[2]
765LHAKIIEKDAMIKVLubiquitination[2]
823AEEKKEEKTWKGSIGubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. 
Sequence Annotation
 MOTIF 953 956 PDZ-binding.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 295 295 Phosphoserine.
 MOD_RES 720 720 Phosphoserine.
 MOD_RES 793 793 Phosphoserine (By similarity).
 MOD_RES 805 805 Phosphoserine (By similarity).
 MOD_RES 906 906 Phosphoserine.  
Keyword
 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Tight junction; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 956 AA 
Protein Sequence
MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE TSALTVEATS 60
SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG TPTENMNLLA 120
IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ 180
PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN 240
SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA 300
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP APQPVRTDVA 360
VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP LPMALGAPQP 420
PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH KFEKELQRIS 480
EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK 540
AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR 600
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH GNGQPANMPE 660
YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA ERDTTIINHS 720
RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA 780
GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH 840
ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS 900
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI 956 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0042802; F:identical protein binding; IDA:MGI.
 GO:0003365; P:establishment of cell polarity involved in ameboidal cell migration; IEA:Compara.
 GO:0035329; P:hippo signaling cascade; TAS:Reactome.
 GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Compara.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR009114; Angiomotin.
 IPR024646; Angiomotin_C. 
Pfam
 PF12240; Angiomotin_C 
SMART
  
PROSITE
  
PRINTS
 PR01807; ANGIOMOTIN.