UniProt Accession

 UBP22_MOUSE; Q5DU02; Q3TU34; Q3U2W4; Q5SU81; Q66JV8; Q6PDX3; Q8BJG3 

Genbank Protein ID

 AK084022; AK220368; AK155071; AK160992; AL646093; BC058419; BC080737 

Genbank Nucleotide ID

 BAC39100.1; BAD90248.1; BAE33026.1; BAE36137.1; CAI25897.1; AAH58419.1; AAH80737.1 

Protein Name

 Ubiquitin carboxyl-terminal hydrolase 22 

Protein Synonyms/Alias

 Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22 

Gene Name

 Usp22 

Gene Synonyms/Alias

 Kiaa1063 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
137	EEQRKAWKMQGVGEK	ubiquitination	[1]
166	KHNPKRRKITSNCTI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity). 

Sequence Annotation

 ZN_FING 61 121 UBP-type.
 ACT_SITE 185 185 Nucleophile (By similarity).
 ACT_SITE 479 479 Proton acceptor (By similarity).
 MOD_RES 129 129 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; Cell cycle; Chromatin regulator; Complete proteome; Hydrolase; Metal-binding; Nucleus; Protease; Reference proteome; Thiol protease; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 525 AA 

Protein Sequence

Gene Ontology

 GO:0000124; C:SAGA complex; IEA:Compara.
 GO:0010485; F:H4 histone acetyltransferase activity; IEA:Compara.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0016578; P:histone deubiquitination; IEA:Compara.
 GO:0016574; P:histone ubiquitination; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0016579; P:protein deubiquitination; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IC:MGI. 

Interpro

 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR001607; Znf_UBP. 

Pfam

 PF00443; UCH
 PF02148; zf-UBP 

SMART

  

PROSITE

 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3
 PS50271; ZF_UBP 

PRINTS