UniProt Accession

 CALM_YEAST; P06787; D6VQA8 

Genbank Protein ID

 M14760; AF081667; X78993; Z35978; AY558184; BK006936 

Genbank Nucleotide ID

 AAA34504.1; AAC68888.1; CAA55612.1; CAA85064.1; AAS56510.1; DAA07228.1 

Protein Name

 Calmodulin 

Protein Synonyms/Alias

 CaM 

Gene Name

 CMD1 

Gene Synonyms/Alias

 YBR109C; YBR0904 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
78	ALMSRQLKSNDSEQE	ubiquitination	[1]
95	EAFKVFDKNGDGLIS	acetylation	[2]
95	EAFKVFDKNGDGLIS	ubiquitination	[1]
116	VLTSIGEKLTDAEVD	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. 

Sequence Annotation

 DOMAIN 8 43 EF-hand 1.
 DOMAIN 44 79 EF-hand 2.
 DOMAIN 81 116 EF-hand 3.
 DOMAIN 117 147 EF-hand 4.
 MOD_RES 82 82 Phosphoserine.
 MOD_RES 102 102 Phosphoserine.  

Keyword

 3D-structure; Calcium; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Metal-binding; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005823; C:central plaque of spindle pole body; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005509; F:calcium ion binding; IDA:SGD.
 GO:0048306; F:calcium-dependent protein binding; IDA:SGD.
 GO:0007114; P:cell budding; IMP:SGD.
 GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IMP:SGD.
 GO:0016237; P:microautophagy; IMP:SGD.
 GO:0006607; P:NLS-bearing substrate import into nucleus; IMP:SGD.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:SGD.
 GO:0006898; P:receptor-mediated endocytosis; IMP:SGD.
 GO:0051300; P:spindle pole body organization; IMP:SGD.
 GO:0042991; P:transcription factor import into nucleus; IMP:SGD.
 GO:0042144; P:vacuole fusion, non-autophagic; IMP:SGD. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS