| Tag | Content |
|---|
| CPLM ID | CPLM-024348 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable helicase senataxin |
Protein Synonyms/Alias | Amyotrophic lateral sclerosis 4 protein homolog; SEN1 homolog |
Gene Name | Setx |
Gene Synonyms/Alias | Als4; Kiaa0625 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 2440 | HDAMKILKLKPVLQR | acetylation | [1] |
|
Reference | [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. J Biol Chem. 2013 Jul 17;. [ PMID: 23864654] |
Functional Description | Probable helicase, which may be involved in RNA maturation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (By similarity). |
Sequence Annotation | NP_BIND 1939 1946 ATP (Potential).
REGION 2632 2646 Necessary for nuclear localization (By
MOTIF 2046 2063 Bipartite nuclear localization signal (By
MOD_RES 1002 1002 Phosphoserine (By similarity).
MOD_RES 1004 1004 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2646 AA |
Protein Sequence | MSTCCWCTPG GSSTIDVLKR YASSTGSSEF QTADEDLCYC LECVAEYHRA RDEVPFLHEV 60
LWELETLRLV SHFEKSMKAE AEDDDDLYIV DNNGEEQLFD CSGQDFENKL RVPLFEILKY 120
PYLLLHERVN ELCVEALCRM EQNNCSFQVF DKYPGIYLFL VHPNEMVRRW AILTARNLGK 180
VDRDDYYDLQ EVLTCLFKVI ELGLLESPDI YTSSVLEKGK LILLPAHMYD TTNYKNYWLG 240
ICMLLTILEE QAMDSLLLGS DKQNDFMQSI LHTMEKQSDD DSMDPFWPAL HCFMVILDRL 300
GSKVWGQLID PIEAFQTIIN NESYNREIQN IRNSSIRTKL EPEPHFDDMV TCSQIVYNFN 360
PEKTKKDSGW RSAICPDYCP NMYEEMETLA NVLQSDIGQD MRVHNSTFLW FIPFVQSLMD 420
LKDLGVAYIV EVIHHLYSEV KDVLNQTDAV CDKVTEFFIL ILISVIELHR NKKCLHLLWV 480
SSQQWVEAVV KCAKLPTTAF VRSCEKSPGS TSRGAAIMSS LALHSVQSNS VQLACVQLIR 540
GLLKEGYQLG QQTLCKRFWD KLNLFLRGNL SLGWQLTGQE THELQMCLKQ IIRNIKFKMP 600
QYSTFGDSTS TFKTPPSFKE ESDKIDRKHK KNIYCLENCS PVSSKEPMKA DTHRVLMKVN 660
TTEEENFKQH YIDLNEEEQE PLPAELCLKQ KSEALFSESA QEQVKISAEK SGKESSSYAP 720
SNSTSRNGPE WGCDRGVIMS AHSLTDSSSD FMEQVSTSNE DVSLKDGSVG KTSKPSFKLQ 780
KDEICAKLSH VIKKQIRKST LVDNIIDLEE NTAISDLENC SGTDGGALKE DSIGHNVPSD 840
PVLDDKHEEQ KSQNSSLFKK EIKSEELDNS SSDDEDKLQI QEGRADDDLV SFTEVTDTLV 900
KAPCEGHVKM VVESRDKEMR ESTALTSNLV EGQVPHDSSK PLVAGRQIDL CNITLISQTT 960
VIQFPSGLSK QNSFQLQKGD KRCLTANQNS AATCRGQVIV ISDSDEEEDE DEDERSSSEE 1020
NIKQSKACIG KDCSEHRSLA VNASVEKQLV KEEERYPVEF EDSESQVFEF ESSSEVFSVW 1080
QDHKIDSKNS LQGEQKSYVT HVADSTNNNL GCGDSVSEEV VRNKAEGVKE HAGPHSSVSA 1140
EEFCKTGVKK PKRKRYDKVT AEDPQRPSSS VGTDQLPDRR DLTESDLKSA DMGMATPSSS 1200
VERDSTILQK STKSRTHSKP VRKVPASKAT KKTHSDTRRG QSKSSCYISC RTSPAIVPPK 1260
KLRQCPEPTS TVEKLGLKKA PRKAFELSQR SLECIVQLRD HGKTVGVVDA PKKAKLISPQ 1320
TLSIKNNKKL LTSQDLQFQR LMRSRSHKKR DFDYKNTDTV RVSRIVQGSD VLEADSDEPD 1380
DHRVSEPLAI SNEKQLAKCM LSKTEVAEAS SDPWVTGITC LVNQCESRVL SGGVPTDVVM 1440
VSASEDPVDG GAVTVQVGEV ASVKAAEPAS SSDTDDDDNL FLTQHDPQDM DLCSQLENKT 1500
IIVAHKKDTV QREDSLSRPQ LESLSITKCK YKDCVETTKN QGEYCPRHSE AKAADDGLFR 1560
KPGLPLSVAR PLRPTTTKIF SSSSASRTAN LSKSLESTTL QQSALKNKSS GAQPNLKVTP 1620
PSSMGSQKPV AEVKSLCNIF HFQTPSSSSK QSCKLTFSEN RPTSAASPVN ILLPSQSIFD 1680
TFIKEVLKWK YQMFLNFDKC GAPTSLCQSI SRPVPVRFQD CAEYFNVFLP LIILNAFETV 1740
AQEWLSSPNK ENFYQLQLRK FPADYKKYWE FLIYLNESEL AKQLHPKEND LVFLAPEKSY 1800
MDRHGMQDCS HYYCGYVHKF RRTSVMRSGK AECSLCIQTQ DTLPASVKNL TRCIVISSLV 1860
TTQRKLKAMS LLSSRNQLAR AVLNPNPMDF CTKDLLTTTS ERIVAYLKDF NEDQKKAIET 1920
AYAMVKHSPS VAKICLIHGP PGTGKSKTIV GLLYRLLTEN QRKGHSDENF NAKIKQNRVL 1980
VCAPSNAAVD ELMKKIILEF KEKCKDKKNP LGNCGDINLV RLGPEKSINT EVLKFSLDSQ 2040
VNHRMKKDLP SHIQEMLRRK EILDAQLDEL SRQRALCRGG REMQRQELDE HIAIVSKERQ 2100
ELASKIKEVQ GRPQRAQNTI ILESHVICCT LSTSGGLLLE SAFRGQGGVP FSCVIVDEAG 2160
QSCEVETLSP LIHRCNKLIL VGDPKQLPPT VISMKAQEYG YDQSMMARFC KLLEENVEQN 2220
MIGRLPVLQL TIQYRMHPDI CLFPSNYVYN KNLKTNRLTE SIRCSSEWPF QPYLVFDVGD 2280
GSERRDNDSY INVQEIKLVM EIIKLIKEKR KDISFRNIGI ITHYKAQKTM IQKDLEKEFD 2340
KKGPAEVDTV DAFQGRQKDC IIVTCVRASA VQGSIGFLAS LQRLNVTITR AKYSLFILGH 2400
LRTLMENQHW YELIQDAQKR GAIIKTSDPN YRHDAMKILK LKPVLQRSLT HPPATAPEAP 2460
RPQGGLPSNR LDSGLATTSF AASLYHTPSD TVTSKGPERP LLQDRLRDPR LLRRLDAEAK 2520
GTFLKDPQPV SPQLPGVVHL LGEPGFPVVF QDLGFVVPPS TAIVAPLGSH RSPMQAEPPP 2580
AHPAAAASTS KRKYSDPDAG LSHKREPRAF SGEQGRHGSV THHVLRSTDW DRRRLDDSSA 2640
KRRQFL 2646 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |