UniProt Accession

 OXYR_ECOLI; P0ACQ4; P11721; P22471; Q2M8Q6 

Genbank Protein ID

 J04553; X52666; X16531; M34102; U00006; U00096; AP009048 

Genbank Nucleotide ID

 AAA24257.1; CAA36893.1; CAA34534.1; AAA24176.1; AAC43067.1; AAC76943.1; BAE77350.1 

Protein Name

 Hydrogen peroxide-inducible genes activator 

Protein Synonyms/Alias

 Morphology and auto-aggregation control protein 

Gene Name

 oxyR 

Gene Synonyms/Alias

 momR; mor; b3961; JW3933 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
38	TLSGQIRKLEDELGV	acetylation	[1]
261	VVYLPCIKPEPRRTI	acetylation	[1]
299	RMDGHFDKVLKQAV*	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability. 

Sequence Annotation

 DOMAIN 1 58 HTH lysR-type.
 DNA_BIND 18 37 H-T-H motif (By similarity).
 MOD_RES 199 199 Cysteine sulfenic acid (-SOH); alternate.
 MOD_RES 199 199 S-glutathionyl cysteine; alternate.
 MOD_RES 199 199 S-nitrosocysteine; alternate.
 DISULFID 180 259
 DISULFID 199 208 Alternate.  

Keyword

 3D-structure; Activator; Complete proteome; Direct protein sequencing; Disulfide bond; DNA-binding; Glutathionylation; Oxidation; Reference proteome; S-nitrosylation; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0000986; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc.
 GO:0001131; F:bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:2000142; P:regulation of DNA-dependent transcription, initiation; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0051409; P:response to nitrosative stress; IDA:EcoCyc.
 GO:0006979; P:response to oxidative stress; IDA:EcoCyc. 

Interpro

 IPR005119; LysR_subst-bd.
 IPR000847; Tscrpt_reg_HTH_LysR.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00126; HTH_1
 PF03466; LysR_substrate 

SMART

  

PROSITE

 PS50931; HTH_LYSR 

PRINTS

 PR00039; HTHLYSR.