CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013708
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein translocase subunit SecA 1 
Protein Synonyms/Alias
  
Gene Name
 secA1 
Gene Synonyms/Alias
 GK3107 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
645VVNAHTPKEEVPEEWacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity). 
Sequence Annotation
 NP_BIND 100 107 ATP (Potential).
 METAL 821 821 Zinc (Potential).
 METAL 823 823 Zinc (Potential).
 METAL 832 832 Zinc (Potential).
 METAL 833 833 Zinc (Potential).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Metal-binding; Nucleotide-binding; Protein transport; Translocation; Transport; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MLGVLKKVFD PNKRQLARLE KIADQVDALG PEMARLSDEQ LRQKTEEFKA RYQQGESLDD 60
LLVEAFAVVR EGAKRVLGLY PYKVQIMGGV VLHEGDIAEM KTGEGKTLTA TMPVYLNALT 120
GRGVHVVTVN EYLATRDATE MGKLYEFLGM TVGLNLSGMS REEKQAAYNA DITYGTNNEF 180
GFDYLRDNMV LYKEHIVQRP LYYAIIDEVD SILIDEARTP LIISGTAQKS TKLYVQANAF 240
VRTLRKDVDY TYDEKTKSVQ LTEEGINKAE RAFGIDNLFD LKHVTLNHHI QLALRAHVTM 300
QRDVDYVVQD GKVIIVDPFT GRLMHGRRYS DGLHQAIEAK EGLEIQNESM TLATITFQNY 360
FRMYEKLAGM TGTAKTEEEE FRNIYNMRVV VIPTNRPVIR EDRPDLIYRT MEGKFRAVVE 420
DIAARHAKGQ PVLVGTVAIE TSEMLSEMLK KRGIPHNVLN AKNHAKEAEI IAQAGQKGAV 480
TIATNMAGRG TDIKLGEGVK ELGGLAVIGT ERHESRRIDN QLRGRSGRQG DPGVSQFYLS 540
LEDELMRRFG SESLMAMMDR LGMDDSQPIQ SKMVTRAVES AQKRVEGNNF DARKQLLQYD 600
DVLREQREII YRQRYEVLDS DNLRGIIEKM IHSVIERVVN AHTPKEEVPE EWNLKGLVEY 660
LNAHLLPEGD VTEADLRGKE PEEMIELIWA KVKARYDEKE AQIPPEQMRE FERVVVLRAV 720
DMKWMHHIDA MEQLRQGIHL RAYGQVDPLR EYQMEGYAMF EEMIAAIEEE VATYIMKAEI 780
HHNLERQEVA KGEAVHPKED GEEPKRKPVR KAVRVGRNDP CPCGSGKKYK HCCGRTV 837 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0065002; P:intracellular protein transmembrane transport; IEA:HAMAP.
 GO:0017038; P:protein import; IEA:InterPro.
 GO:0006605; P:protein targeting; IEA:HAMAP. 
Interpro
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR004027; SEC_C_motif.
 IPR000185; SecA.
 IPR020937; SecA_CS.
 IPR011115; SecA_DEAD.
 IPR014018; SecA_motor_DEAD.
 IPR011130; SecA_preprotein_X-link_dom.
 IPR011116; SecA_Wing/Scaffold. 
Pfam
 PF00271; Helicase_C
 PF02810; SEC-C
 PF07517; SecA_DEAD
 PF01043; SecA_PP_bind
 PF07516; SecA_SW 
SMART
 SM00957; SecA_DEAD
 SM00958; SecA_PP_bind 
PROSITE
 PS01312; SECA
 PS51196; SECA_MOTOR_DEAD 
PRINTS
 PR00906; SECA.