UniProt Accession

 A2A7S7_MOUSE; A2A7S7 

Genbank Protein ID

 AL606977; CH466552 

Genbank Nucleotide ID

 EDL30209.1 

Protein Name

 Tyrosine--tRNA ligase, cytoplasmic 

Protein Synonyms/Alias

 Tyrosyl-tRNA synthetase 

Gene Name

 Yars 

Gene Synonyms/Alias

 mCG_141662 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
83	WGTATTGKPHVAYFV	acetylation	[1]
94	AYFVPMSKIADFLKA	acetylation	[1]
150	SIGVPLEKLKFIKGT	acetylation	[1]
155	LEKLKFIKGTDYQLS	acetylation	[1]
233	KIFTFAEKYLPALGY	ubiquitination	[2]
242	LPALGYSKRVHLMNP	ubiquitination	[2]
308	KHVLFPLKSEFVILR	acetylation	[1]
371	FNTPALKKLASAAYP	ubiquitination	[2]
448	GLVQFVPKEELQDRL	acetylation	[3]
463	VVVLCNLKPQKMRGV	acetylation	[1]
549	KQTNFMTKLGFVSCK	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 564 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0000049; F:tRNA binding; IEA:InterPro.
 GO:0004831; F:tyrosine-tRNA ligase activity; IEA:InterPro.
 GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:InterPro. 

Interpro

 IPR002305; aa-tRNA-synth_Ic.
 IPR012340; NA-bd_OB-fold.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR002547; tRNA-bd_dom.
 IPR002307; Tyr-tRNA-ligase.
 IPR023617; Tyr-tRNA-ligase_arc/euk-type. 

Pfam

 PF00579; tRNA-synt_1b
 PF01588; tRNA_bind 

SMART

  

PROSITE

 PS50886; TRBD 

PRINTS

 PR01040; TRNASYNTHTYR.