CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 12 
Protein Synonyms/Alias
 Ankyrin repeat-containing cofactor 2; GAC-1 protein 
Gene Name
 ANKRD12 
Gene Synonyms/Alias
 ANCO2; KIAA0874 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39DKIASYSKTPKIERSacetylation[1]
675EIEGEKEKYKTKDSAubiquitination[2]
926ERHLAESKEKHLMEKubiquitination[3]
928HLAESKEKHLMEKKNmethylation[4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. 
Sequence Annotation
 REPEAT 184 213 ANK 1.
 REPEAT 217 246 ANK 2.
 REPEAT 250 280 ANK 3.
 MOD_RES 149 149 Phosphoserine.
 MOD_RES 861 861 Phosphoserine.  
Keyword
 Alternative splicing; ANK repeat; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2062 AA 
Protein Sequence
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR 60
KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TKKEAGNKKS 120
TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK 180
RNERGETPLH MAAIRGDVKQ VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA 240
GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL 300
KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS KTPLPSALDE 360
YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA KQEKAFYPKS FKSKKQKPSR 420
VLYSSTESSD EEALQNKKIS TSCSVIPETS NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN 480
KNKENQELKQ EKEGKENTRI TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST 540
GKSPKHSCGL SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC 600
KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL KKHKLKHKER 660
EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF FKSDETEDLF LNMEHESLTL 720
EKKSKLEKNI KDDKSTKEKH VSKERNFKEE RDKIKKESEK SFREEKIKDL KEERENIPTD 780
KDSEFTSLGM SAIEESIGLH LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT 840
FEKEKKIKHE HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR 900
EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK NKEKDRELDK 960
KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL KEKTKDEPLK TPDGKEKDKK 1020
DKDIDRYKER DKHKDKIQIN SLLKLKSEAD KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF 1080
ERMLSLKDLE IEQWHKKHKE KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR 1140
SKSSEVTDAY TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS 1200
SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL SIAKSPALHE 1260
RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE GRPTIEVRRC SMPSVICEHT 1320
KQFQTISEES NQGSLLTVPG DTSPSPKPEV FSNVPERDLS NVSNIHSSFA TSPTGASNSK 1380
YVSADRNLIK NTAPVNTVMD SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN 1440
IPDQESSLQS FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS 1500
DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV LGDVQKTDAF 1560
VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL NTHYAFSKLT YKSSSGHEVE 1620
NSTTDTQVIS HEKENKLESL VLTHLSRCDS DLCEMNAGMP KGNLNEQDPK HCPESEKCLL 1680
SIEDEESQQS ILSSLENHSQ QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA 1740
NTMANQSKQI LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP 1800
SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR KLLCSVIPQA 1860
PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFRQQEVVR MKLRLQHSIE 1920
REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDSQS DDSKTSVRDR 1980
FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI 2040
YEIQEFYVPL VDVNDDFELT PI 2062 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF00023; Ank
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.