UniProt Accession

 CATZ_HUMAN; Q9UBR2; B2RC40; O75331; Q9UQV5; Q9UQV6 

Genbank Protein ID

 AF073890; AF032906; AF136273; AF136276; AF136274; AF136275; AK314931; AL109840; CH471077; BC042168; AF009923 

Genbank Nucleotide ID

 AAC61477.1; AAC39839.1; AAF13145.1; AAF13148.1; AAF13148.1; AAF13148.1; BAG37437.1; CAC09370.1; EAW75448.1; AAH42168.1; AAC63141.1 

Protein Name

 Cathepsin Z 

Protein Synonyms/Alias

 Cathepsin P; Cathepsin X 

Gene Name

 CTSZ 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
166	AKDQECDKFNQCGTC	ubiquitination	[1]
177	CGTCNEFKECHAIRN	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. 

Sequence Annotation

 ACT_SITE 92 92
 ACT_SITE 241 241
 ACT_SITE 261 261
 CARBOHYD 184 184 N-linked (GlcNAc...).
 CARBOHYD 224 224 N-linked (GlcNAc...) (Potential).
 DISULFID 89 132
 DISULFID 126 164
 DISULFID 154 170
 DISULFID 173 179
 DISULFID 214 296  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008234; F:cysteine-type peptidase activity; TAS:ProtInc.
 GO:0002003; P:angiotensin maturation; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Compara.
 GO:0006508; P:proteolysis; TAS:ProtInc. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C. 

Pfam

 PF00112; Peptidase_C1 

SMART

 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.