CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020161
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DCN1-like protein 5 
Protein Synonyms/Alias
 DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5 
Gene Name
 DCUN1D5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MPVKKKRKSPGVAAAubiquitination[1]
23VAEDGGLKKCKISSYubiquitination[2]
24AEDGGLKKCKISSYCubiquitination[1]
26DGGLKKCKISSYCRSubiquitination[1]
49GEEHFSSKKCLAWFYubiquitination[1]
50EEHFSSKKCLAWFYEubiquitination[1]
120LQCDCTEKLQNKFDFubiquitination[1]
124CTEKLQNKFDFLRSQubiquitination[1]
139LNDISSFKNIYRYAFubiquitination[2, 3, 4, 5]
194SKYRVMNKDQWYNVLubiquitination[1, 2, 3, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 DOMAIN 46 232 DCUN1.
 MOD_RES 9 9 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK CLAWFYEYAG 60
PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF FTKEEWLKGM TSLQCDCTEK 120
LQNKFDFLRS QLNDISSFKN IYRYAFDFAR DKDQRSLDID TAKSMLALLL GRTWPLFSVF 180
YQYLEQSKYR VMNKDQWYNV LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS 237 
Gene Ontology
  
Interpro
 IPR014764; DCN-prot.
 IPR005176; PONY_dom. 
Pfam
 PF03556; Cullin_binding 
SMART
  
PROSITE
 PS51229; DCUN1 
PRINTS