CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-secretase subunit APH-1A 
Protein Synonyms/Alias
 APH-1a; Aph-1alpha; Presenilin-stabilization factor 
Gene Name
 APH1A 
Gene Synonyms/Alias
 PSF; CGI-78; UNQ579/PRO1141 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92VFRFAYYKLLKKADEubiquitination[1]
95FAYYKLLKKADEGLAubiquitination[1]
96AYYKLLKKADEGLASubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 265 AA 
Protein Sequence
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT 60
DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV 120
SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD 180
ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ 240
RSLLCRRQED SRVMVYSALR IPPED 265 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:HGNC.
 GO:0004175; F:endopeptidase activity; IEA:Compara.
 GO:0042987; P:amyloid precursor protein catabolic process; IMP:UniProtKB.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
 GO:0031293; P:membrane protein intracellular domain proteolysis; IMP:UniProtKB.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007220; P:Notch receptor processing; IMP:UniProtKB.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
 GO:0016485; P:protein processing; IDA:HGNC. 
Interpro
 IPR009294; Aph-1. 
Pfam
 PF06105; Aph-1 
SMART
  
PROSITE
  
PRINTS