CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015842
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit delta 
Protein Synonyms/Alias
 TCP-1-delta; CCT-delta 
Gene Name
 Cct4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
288AYILNLVKQIKKTGCacetylation[1]
321LHFLNKMKIMVVKDIacetylation[1]
395IVVRGSNKLVIEEAEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). 
Sequence Annotation
 MOD_RES 288 288 N6-acetyllysine (By similarity).
 MOD_RES 302 302 N6-acetyllysine (By similarity).
 MOD_RES 319 319 N6-acetyllysine (By similarity).
 MOD_RES 326 326 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 539 AA 
Protein Sequence
MPENVASRSG PPAAGPGNRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT SLGPKGMDKM 60
IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI EAGDGTTSVV IIAGSLLDSC 120
TKLLQKGIHP TIISESFQKA LEKGLEILTD MSRPVQLSDR ETLLNSATTS LNSKVVSQYS 180
SLLSPMSVNA VMKVIDPATA TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVANSGITR 240
VEKAKIGLIQ FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI 300
QKSILRDALS DLALHFLNKM KIMVVKDIER EDIEFICKTI GTKPVAHIDQ FTPDMLGSAE 360
LAEEVSLNGS GKLFKITGCT SPGKTVTIVV RGSNKLVIEE AERSIHDALC VIRCLVKKRA 420
LIAGGGAPEI ELALRLTEYS RTLSGMESYC VRAFADAMEV IPSTLAENAG LNPISTVTEL 480
RNRHAQGEKT TGINVRKGGI SNILEEMVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR 539 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005832; C:chaperonin-containing T-complex; IEA:Compara.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051082; F:unfolded protein binding; TAS:RGD.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; TAS:RGD. 
Interpro
 IPR012717; Chap_CCT_delta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.